Results 81 to 90 of about 2,270,763 (304)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Nurture of Nature: Biology, Psychology and Culture [PDF]

, 2010
In this thesis I explore what consequences taking development seriously in evolutionary considerations will have for how we understand the evolution of psychology and culture.
Hannon, Elizabeth Mary, HANNON, ELIZABETH,MARY   +1 more
core  

Divergence in larval jaw gene expression reflects differential trophic adaptation in haplochromine cichlids prior to foraging [PDF]

, 2019
BackgroundUnderstanding how variation in gene expression contributes to morphological diversity is a major goal in evolutionary biology. Cichlid fishes from the East African Great lakes exhibit striking diversity in trophic adaptations predicated on the ...
Wolfgang Gessl, Duenser, Anna, Ahi, Ehsan Pashay, Sturmbauer, Christian, Duenser, Anna,, Sturmbauer, Christian,, Ahi, Ehsan Pashay,, Pooja Singh, Anna Duenser, Ehsan Pashay Ahi, Singh, Pooja,, Gessl, Wolfgang, Pashay Ahi, Ehsan, Singh, Pooja, Gessl, Wolfgang,, Christian Sturmbauer   +15 more
core   +1 more source

The amylase gene cluster in house mice (Mus musculus) was subject to repeated introgression including the rescue of a pseudogene

BMC Evolutionary Biology, 2020
Background Amylase gene clusters have been implicated in adaptive copy number changes in response to the amount of starch in the diet of humans and mammals. However, this interpretation has been questioned for humans and for mammals there is a paucity of
Miriam Linnenbrink, Kristian K. Ullrich, Ellen McConnell, Diethard Tautz   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Philosophy of Molecular and Developmental Biology [PDF]

, 2000
Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction.
Griffiths, Paul Edmund
core  

Cathedrals, Corals and Mycelia: Three Analogies for the History of Evolutionary Biology

, 2021
In The Structure of Evolutionary Theory, Stephen Jay Gould argued that the history and structure of the evolutionary theory could be represented as a fossilized coral constituted by a central branch representing the mechanism of natural selection.
M. Esposito, Maurizio Esposito
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Tracing the path from conservation to expansion evolutionary insights into NLR genes in oleaceae

BMC Plant Biology
The Oleaceae family, encompassing key genera such as Fraxinus (ash trees), Olea (olives), Jasminum (jasmine), Syringa (lilac), and Forsythia, plays a crucial ecological and economic role.
Saba Parvez, Maryam Asif, Alizay Ahmad, Iqra Javaid, Muhammad Zaman Rasheed, Romana Iftikhar, Nada H. Aljarba, Rabia Zafar, Aqsa sarwar, Rao Sohail Ahmed Khan, Saad Serfraz   +10 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source