Results 101 to 110 of about 2,270,763 (304)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The tragedy of the commons in evolutionary biology [PDF]

, 2007
Garrett Hardin's tragedy of the commons is an analogy that shows how individuals driven by self-interest can end up destroying the resource upon which they all depend.
Rankin, Daniel J., Kokko, H., Rankin, Daniel J, Bargum, Katja, Kokko, Hanna   +4 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

In what sense does 'nothing make sense except in the light of evolution'? [PDF]

, 2008
Dobzhansky argued that biology only makes sense if life on earth has a shared history. But his dictum is often reinterpreted to mean that biology only makes sense in the light of adaptation.
Paul Edmund Griffiths, Griffiths, Paul Edmund   +1 more
core   +1 more source

Why rapid, adaptive evolution matters for community dynamics

Frontiers in Ecology and Evolution, 2014
Evolution on contemporary timescales has recently been recognized as an important driver for ecological change. It is now well established that evolutionary change can affect the interactions between species within a few generations and that ecological ...
Hanna eKoch, Jens eFrickel, Martha eValiadi, Lutz eBecks   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Range expansion and habitat shift triggered elevated diversification of the rice genus (Oryza, Poaceae) during the Pleistocene [PDF]

, 2015
Background: The rice genus (Oryza) contains many wild genetic resources that are vital to the well-being of humans. However, little is known about the process by which the genus diversified or the factors that drove its speciation.
Yun-Jun Bai, Zhi-Duan Chen, Wang, Wei, Tang, Zhi-Yao, Liang Tang, Li Lin, Chen, Zhi-Duan, Lin, Li, Bai, Yun-Jun, Zhi-Yao Tang, Wei Wang, Tang, Liang   +11 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Multiple differences in calling songs and other traits between solitary and gregarious Mormon crickets from allopatric mtDNA clades [PDF]

, 2014
The Linnaean Society, The British Ecological Society, The Russell Trust (St. Andrews), The Orthopterists' Society and an NSERC (Canada) grant to DTG. Gordon S.
Ritchie, Michael G., Bailey, William V., Bailey, Nathan William, Gwynne, Darryl T.   +3 more
core   +1 more source