Results 111 to 120 of about 1,003,364 (349)
Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis [PDF]
, 2022 Stanislav Kotlyarov
openalex +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Ernst Mayr and Evolutionary Biology [PDF]
Evolution, 1994 It is possible to feel such communion with the works of our scientific predecessors as to inspire not only admiration, but also gratitude and even affection. Long before I met him, Ernst Mayr had profoundly affected my development, for probably the most influential event of my graduate education had been a year-long, line-by-line exegesis, in a ...
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Does Mother Nature Punish Rotten Kids? [PDF]
This paper studies the evolutionary game theory of parent-offspring conflict. It revisits a question posed by Gary Becker in economics and Richard Alexander in biology, namely "when do children act in accord with the reproductive interests of their ...
Carl Bergstrom, Ted Bergstrom
core
, 1999 This volume of twelve specially commissioned essays about species draws on the perspectives of prominent researchers from anthropology , botany, developmental psychology , the philosophy of biology and science, protozoology, and zoology .
Wilson, Robert A.
core
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Session 5: Development, Neuroscience and Evolutionary Psychology [PDF]
, 2002 Proceedings of the Pittsburgh Workshop in History and Philosophy of Biology, Center for Philosophy of Science, University of Pittsburgh, March 23-24 2001 Session 5: Development, Neuroscience and Evolutionary ...
Machamer, Peter +3 more
core
Effects of Epistasis and Pleiotropy on Fitness Landscapes
, 2013 The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid +15 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source