Results 121 to 130 of about 2,270,763 (304)

Systems evolutionary biology : biological network evolution theory, stochastic evolutionary game strategies, and applications to systems synthetic biology /

open access: yes
Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks ...
Chen, Bor-Sen,author.
core  

Dancing in the Dark: Evolutionary Psychology and the Problem of Design [PDF]

open access: yes, 2001
The current Evolutionary Psychology Movement (EPM) argues that the mind/brain cannot be understood except by conceiving of it as the product of design by natural selection.
Griffiths, Paul E., Stotz, Karola
core  

Patterns of gene flow and selection across multiple species of Acrocephalus warblers: footprints of parallel selection on the Z chromosome [PDF]

open access: yes
Background: Understanding the mechanisms and selective forces leading to adaptive radiations and origin of biodiversity is a major goal of evolutionary biology.
Jiří Reif   +5 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

The evolutionary potential of host-associated microbiomes

open access: yes, 2022
The microbiome has emerged as an important regulator of many different aspects of organismal biology—however, the evolutionary implications remain enigmatic.
Henry, Lucas Price
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Session 5: Development, Neuroscience and Evolutionary Psychology [PDF]

open access: yes, 2002
Proceedings of the Pittsburgh Workshop in History and Philosophy of Biology, Center for Philosophy of Science, University of Pittsburgh, March 23-24 2001 Session 5: Development, Neuroscience and Evolutionary ...
Quartz, Steven   +3 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Evolutionary Theory in the 1920s: The Nature of the 'Synthesis' [PDF]

open access: yes, 2002
This paper analyzes the development of evolutionary theory in the period from 1918 to 1932. It argues that: (i) Fisher's work in 1918 constitutes a not fully satisfactory reduction of biometry to Mendelism; (ii) that there was a synthesis in the 1920s ...
Sarkar, Sahotra
core  

Evolutionary dynamics and population biology of a polymorphic insect

open access: yes, 2005
Conspicuous heritable polymorphisms are useful to address the question if morph frequencies are stable or whether they fluctuate between generations.
Svensson, Erik,   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy