Results 101 to 110 of about 1,205,745 (301)

Evolutionary multiobjective optimization: open research areas and some challenges lying ahead

Complex & Intelligent Systems, 2019
Evolutionary multiobjective optimization has been a research area since the mid-1980s, and has experienced a very significant activity in the last 20 years. However, and in spite of the maturity of this field, there are still several important challenges
Carlos A. Coello Coello, Silvia González Brambila, Josué Figueroa Gamboa, Ma Guadalupe Castillo Tapia, Raquel Hernández Gómez   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

RFreak-An R-package for evolutionary computation [PDF]

RFreak is an R package providing a framework for evolutionary computation. By enwrapping the functionality of an evolutionary algorithm kit written in Java, it offers an easy way to do evolutionary computation in R.
Nunkesser, Robin
core  

On improving approximate solutions by evolutionary algorithms [PDF]

, 2007
Hybrid methods are very popular for solving problems from combinatorial optimization. In contrast to this the theoretical understanding of the interplay of different optimization methods is rare.
Witt, Carsten, Carsten Witt, Neumann, Frank, Friedrich, T., He, Jun, Witt, C., Neumann, F., Frank Neumann, Friedrich, Tobias, Jun He, Hebbinghaus, Nils, He, J., Tobias Friedrich, Hebbinghaus, N., Nils Hebbinghaus   +14 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Towards Drift Correction in Chemical Sensors Using an Evolutionary Strategy [PDF]

, 2010
Gas chemical sensors are strongly affected by the so-called drift, i.e., changes in sensors' response caused by poisoning and aging that may significantly spoil the measures gathered.
Squillero, Giovanni, Ernesto Sanchez, Alberto Paolo Tonda, Tonda, A., Stephano Di Carlo, SANCHEZ SANCHEZ, EDGAR ERNESTO, Giovanni Squillero, Matteo Falasconi, Alberto Scionti, Di Carlo, Stefano, Scionti, A., Sanchez, E., Falasconi, M.   +12 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A modified indicator-based evolutionary algorithm (mIBEA) [PDF]

, 2017
Multi-objective evolutionary algorithms (MOEAs) based on the concept of Pareto-dominance have been successfully applied to many real-world optimisation problems.
Li, Wenwen, Li, W., Drake, J.H., Wenwen Li, John H. Drake, Aneta Neumann, Markus Wagner, Özcan, Ender, Özcan, E, Robert John, John, R.I., Neumann, A, Wagner, M., Neumann, A., John, R, John, Robert, Drake, John H., Drake, JH, Wagner, M, Ender Ozcan, Neumann, Aneta, Li, W, Özcan, E., Wagner, Markus   +23 more
core   +1 more source