Results 81 to 90 of about 253,415 (278)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Some Computational Aspects of Essential Properties of Evolution and Life [PDF]

, 2012
While evolution has inspired algorithmic methods of heuristic optimisation, little has been done in the way of using concepts of computation to advance our understanding of salient aspects of biological evolution.
Hector Zenil, James A. R. Marshall
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evolutionary multiobjective optimization: open research areas and some challenges lying ahead

Complex & Intelligent Systems, 2019
Evolutionary multiobjective optimization has been a research area since the mid-1980s, and has experienced a very significant activity in the last 20 years. However, and in spite of the maturity of this field, there are still several important challenges
Carlos A. Coello Coello, Silvia González Brambila, Josué Figueroa Gamboa, Ma Guadalupe Castillo Tapia, Raquel Hernández Gómez   +4 more
doaj   +1 more source

Elitism Levels Traverse Mechanism For The Derivation of Upper Bounds on Unimodal Functions [PDF]

, 2012
In this article we present an Elitism Levels Traverse Mechanism that we designed to find bounds on population-based Evolutionary algorithms solving unimodal functions. We prove its efficiency theoretically and test it on OneMax function deriving bounds c{
Ter-Sarkisov, Aram
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Optimal adaptive coordination of overcurrent relays in power systems protection using a new hybrid metaheuristic algorithm

IET Renewable Power Generation
Advent of distributed generation and progression towards an intelligent grid infrastructure within the domain of contemporary electrical power systems have created dynamic load profiles.
Samira Sadeghi, Ali Hesami Naghshbandy, Parham Moradi, Abed Bagheri   +3 more
doaj   +1 more source

Review of Reinforcement Learning and Evolutionary Computation Methods for StrategyExploration [PDF]

Jisuanji kexue
Reinforcement learning and evolutionary computation,as two types of nature-inspired learning paradigms,are the mainstream methods for solving strategy exploration problems,and the fusion of these two types of methods provides a general solution for ...
WANG Yao, LUO Junren, ZHOU Yanzhong, GU Xueqiang, ZHANG Wanpeng
doaj   +1 more source