Results 51 to 60 of about 253,604 (271)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
ECF: A C＋＋ framework for evolutionary computation
SoftwareXMetaheuristics have been shown to be efficient techniques for addressing a wide range of complex optimization problems. Developing flexible, reliable, and efficient frameworks for evolutionary computation metaheuristics is of great importance.
Domagoj Jakobovic +3 more
doaj +1 more source
GA Approach to Optimize Training Client Set in Federated Learning
IEEE Access, 2023 Federated learning, where the distribution of distributed data is unknown, is more difficult and costly to train a central model with than traditional machine learning.
Dongseok Kang, Chang Wook Ahn
doaj +1 more source
Computation Environments, An Interactive Semantics for Turing Machines (which P is not equal to NP considering it) [PDF]
, 2012 To scrutinize notions of computation and time complexity, we introduce and formally define an interactive model for computation that we call it the \emph{computation environment}.
Ramezanian, Rasoul
core
Exploring tradeoffs in pleiotropy and redundancy using evolutionary computing
, 2004 Evolutionary computation algorithms are increasingly being used to solve optimization problems as they have many advantages over traditional optimization algorithms.
Abbott, Derek +5 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
A Review of Gait Optimization Based on Evolutionary Computation
Applied Computational Intelligence and Soft Computing, 2010 Gait generation is very important as it directly affects the quality of locomotion of legged robots. As this is an optimization problem with constraints, it readily lends itself to Evolutionary Computation methods and solutions.
Daoxiong Gong, Jie Yan, Guoyu Zuo
doaj +1 more source
Quality Diversity: A New Frontier for Evolutionary Computation
Frontiers in Robotics and AI, 2016 While evolutionary computation and evolutionary robotics take inspiration from nature, they have long focused mainly on problems of performance optimization.
Justin K Pugh +2 more
doaj +1 more source
IEEE Access, 2020 Binary butterfly optimization approach (bBOA) is a recent high performing feature selection algorithm presented in 2018 which is based on the food foraging behavior of butterflies.
Bo Zhang +4 more
doaj +1 more source