Results 91 to 100 of about 2,645,282 (301)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Evolution and Developmental Diversity of Skin Spines in Pufferfishes
iScience, 2019 Summary: Teleost fishes develop remarkable varieties of skin ornaments. The developmental basis of these structures is poorly understood. The order Tetraodontiformes includes diverse fishes such as the ocean sunfishes, triggerfishes, and pufferfishes ...
Takanori Shono +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Role a Concept Plays in Science - The Case of Homology [PDF]
, 2003 The present paper gives a description and philosophical analysis of the conceptual variation in the homology concept. It is argued that different homology are concepts used in evolutionary and comparative biology, in developmental biology, and in ...
Brigandt, Ingo
core
In what sense does 'nothing make sense except in the light of evolution'? [PDF]
, 2008 Dobzhansky argued that biology only makes sense if life on earth has a shared history. But his dictum is often reinterpreted to mean that biology only makes sense in the light of adaptation.
Paul Edmund Griffiths +1 more
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Evolutionary Psychology as a Metatheory for the Social Sciences [PDF]
Integral Review, 2010 Evolutionary psychology has been proposed as a metatheory for the social sciences. In this paper, the different ways in which scholars have used the concept of a metatheory in the field of evolutionary psychology is reviewed. These different ways include
Annemie Ploeger
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Session 5: Development, Neuroscience and Evolutionary Psychology [PDF]
, 2002 Proceedings of the Pittsburgh Workshop in History and Philosophy of Biology, Center for Philosophy of Science, University of Pittsburgh, March 23-24 2001 Session 5: Development, Neuroscience and Evolutionary ...
Quartz, Steven +3 more
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Celebrating 100 years of Developmental Biology at the Hubrecht Institute
, 2017 This special issue of Developmental Biology is to celebrate the 100th anniversary of the Hubrecht Institute for Developmental Biology and Stem Cell ...
Jeroen den Hertog +5 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source