Results 151 to 160 of about 3,953,318 (310)
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Heterogeneity and Evolutionary Change - Empirical Conception, Findings and Unresolved Issues [PDF]
In this position paper we deal with the conception of heterogeneity as both the force and the result of evolutionary change. We ask, how this heterogeneity can be measured empirically and how we can get a measure which allows to get a broad comparable ...
Horst Hanusch, Uwe Cantner
core
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Local stability under evolutionary game dynamics [PDF]
We prove that any regular ESS is asymptotically stable under any impartial pairwise comparison dynamic, including the Smith dynamic; under any separable excess payoff dynamic, including the BNN dynamic; and under the best response dynamic.
Sandholm, William H.
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Evolutionary Dynamics of Globalization [PDF]
The expansion of markets –globalization– was reversed during early 20th century and unfettered markets gave in to the welfare state and central planning. But the markets have been striking back since the early 1980s.
Hüseyin Ozel, Naci Canpolat
core
Evolutionary ecology of hares (Lepus spp.) from northwest Africa: the existence of cryptic species and description of a new species (Lepus saharae sp. nov.) [PDF]
, 2019 Objective: We examine the different pressures that lead to the occurrence of new species and thus to their phylogenies. From an evolutionary ecology perspective, we examine the phylogenetic relationships of different lineages, as well as the evolutionary
Donat-Torres, Maria Pilar +3 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
An evolutionary model for the dynamics of vertical integration and network-based production [PDF]
The concept of modularity has gained recently a growing attention in the management literature as a key to explain the contemporary trends of industrial dynamics.
Leonardo Bargigli
core
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source