Results 81 to 90 of about 38,842 (262)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

On maximal regularity for a class of evolutionary equations

Journal of Mathematical Analysis and Applications, 2017
The issue of so-called maximal regularity is discussed within a Hilbert space framework for a class of evolutionary equations. Viewing evolutionary equations as a sums of two unbounded operators, showing maximal regularity amounts to establishing that the operator sum considered with its natural domain is already closed.
Rainer Picard, Sascha Trostorff, Marcus Waurick   +2 more
openaire   +3 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Numerical Analysis of Evolutionary Equations with Multivalued Interaction Functions

Journal of Optimization, Differential Equations and Their Applications
This paper serves as a continuation of previous research on approximating solutions for reaction-diffusion equations with multivalued interaction functions.
Pavlo O. Kasyanov, Oleksiy V. Kapustyan, Liudmyla B. Levenchuk, Vladyslav R. Novykov, Liliia S. Paliichuk   +4 more
doaj   +1 more source

The Evolutionary Properties on Solitary Solutions of Nonlinear Evolution Equations

Advances in Mathematical Physics, 2017
The evolution process of four class soliton solutions is investigated by basic calculus theory. For any given x, we describe the special curvature evolution following time t for the curve of soliton solution and also study the fluctuation of solution ...
Wenxia Chen, Danping Ding, Xiaoyan Deng, Gang Xu   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Boundary-value problems in a layer for evolutionary pseudo-differential equations with integral conditions

Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2018
Boundary-value problems for evolutionary pseudo-differential equations with an integral condition are studied. Necessary and sufficient conditions of well-posedness are obtained for these problems in the Schwartz spaces.
A. A. Makarov, D. A. Levkin
doaj  

Asymptotical solutions for a vibrationally relaxing gas

Mathematical Modelling and Analysis, 2009
Using the weakly non‐linear geometrical acoustics theory, we obtain the small amplitude high frequency asymptotic solution to the basic equations governing one dimensional unsteady planar, spherically and cylindrically symmetric flow in a vibrationally ...
Rajan Arora
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source