Results 71 to 80 of about 41,570 (295)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Cauchy Problems for Evolutionary Pseudodifferential Equations over p-Adic Field

Abstract and Applied Analysis, 2014
We study a class of evolutionary pseudodifferential equations of the second order in t,  (∂2u(t,x)/∂t2+2a2Tα/2(∂u(t,x)/∂t)+b2Tαu(t,x)+c2u(t,x)=q(t,x)), where t∈(0,z] and Tα is pseudodifferential operator in x∈Qp, which defined by Weiyi Su in 1992.
Bo Wu, Yin Li, Weiyi Su
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Evolutionary Method for Nonlinear Systems of Equations [PDF]

, 2006
We propose a new perspective for solving systems of nonlinear equations by viewing them as a multiobjective optimization problem where every equation represents an objective function whose goal is to minimize the difference between the right- and left-hand side of the corresponding equation of the system.
Crina Grosan, Ajith Abraham, Alexander F. Gelbukh   +2 more
openaire   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Method of approximation of evolutionary inclusions and variational inequalities bi stationary

Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2019
The method of finite-difference approximations, advanced by C. Bardos and H. Brezis for the nonlinear evolutionary equations, is generalized on differential-operational inclusions which are tightly connected to evolutionary variational inequalities in ...
P. O. Kasyanov, V. S. Mel’nik, L. Toscano   +2 more
doaj  

A Literature Review of Stochastic Modeling for Phylogenetic Comparative Analysis in Trait Evolution

Mathematics
Evolutionary inferences from phylogenetic trees can be modeled stochastically using a range of mathematical frameworks. Among these, stochastic differential equations (SDEs) provide a particularly flexible and powerful approach to capturing the ...
Dwueng-Chwuan Jhwueng
doaj   +1 more source