Phase Ib/II Study of the Safety and Efficacy of Combination Therapy with Multikinase VEGF Inhibitor Pazopanib and MEK Inhibitor Trametinib In Advanced Soft Tissue Sarcoma. [PDF]
, 2017 Purpose: Pazopanib, a multireceptor tyrosine kinase inhibitor targeting primarily VEGFRs1–3, is approved for advanced soft tissue sarcoma (STS) and renal cell cancer. Downstream of VEGFR, trametinib is an FDA-approved MEK inhibitor used for melanoma.
Azad, Nilofe A. +10 more
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Osteomielitis y tumor de Ewing: aspectos clínicos y radiográficos comunes [PDF]
, 1992 La osteomielitis aguda y el tumor de Ewing, dos entidades de naturaleza bien distinta, pueden mostrar semejanzas clínicas y radiográficas. Presentamos un caso de tumor de Ewing clásico y dos de osteomielitis que plantearon sendas dudas diagnósticas ...
Domínguez Hernández, J. +4 more
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Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter
Scientific ReportsWe recently demonstrated that GGAA promoters (GGAAprom) can be used to drive the expression of therapeutic genes (i.e., Cas9) in vitro and in vivo in a highly specific way in Ewing sarcoma cells.
Saint T. Cervera +4 more
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Treatment of Ewing Sarcoma, Paediatric Bone Sarcomas and Severe Paediatric Spinal Deformities in Finland [PDF]
, 2017 Background: Ewing sarcomas are rare highly malignant tumours. There are not many population-based studies including both bone and soft tissue tumours. Previous reports have suggested that the incidence of Ewing sarcoma in the paediatric population may be
Serlo, Joni
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Analysis of Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Collagen Iα1 Genes and Their Relationship With Height in Children With Bone Cancer [PDF]
, 2003 The authors' objectives were to compare height at diagnosis of children with bone tumors with that of Spanish reference children; to analyze the frequency of the genotypes for the polymorphisms of the vitamin D receptor (VDR ...
Azcona-San-Julian, M.C. (María Cristina) +4 more
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Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma
Nature CommunicationsEwing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse and die of the disease due to chemoresistance.
Le Yu +6 more
doaj +1 more source
Using immunostains to distinguish the look-alike Blue Cell Tumors, their pathogenesis and behavior: Experience of a single center in Khartoum [PDF]
Blue cell tumours are a diverse group that look alike in the H&E stained sections and are difficult to distinguish from each other except by immunohistochemistry. They include: Desmoplastic small-round-cell tumour, Ewing's Sarcoma/PNET, Neuroblastoma,
EL Hassan, Ahmed M
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Cancer ReportsBackground Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when the ...
Fabio Murtas +11 more
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Ewing sarcoma of the uterus: A case report
Case Reports in Women's HealthA case is described of Ewing sarcoma of the uterus, an atypical presentation of an already rare cancer.A 55-year-old woman presented with abdominal pain, abnormal uterine bleeding and a uterine mass that measured 11 × 10 × 14.5 cm and demonstrated ...
Zeynep Tek +4 more
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Ewing′s Sarcoma of the Ramus of Mandible - Report of a Case
Journal of Indian Academy of Oral Medicine and Radiology, 2007 Ewing′s Sarcoma is a highly lethal round cell sarcoma of unknown etiology that was first described by ′James Ewing′ in 1921. Ewing′s sarcoma is one of the most aggressive bone tumors known and accounts for 4-7% of primary bone malignancies.
Mubeen +2 more
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