Results 81 to 90 of about 19,217 (182)

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He   +2 more
wiley   +1 more source

Ewing Sarcoma of the Spine: Prognostic Variables for Survival and Local Control in Surgically Treated Patients

open access: yesGlobal Spine Journal, 2015
Introduction Primary Ewing sarcoma of the spine is a challenging tumor to treat because of a high rate of local recurrence. The optimum role of surgery in the treatment of Ewing sarcoma is not clearly defined.
Laurence Rhines   +12 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

open access: yesThe FEBS Journal, Volume 293, Issue 13, Page 3991-4013, July 2026.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto   +9 more
wiley   +1 more source

Ewing's sarcoma [PDF]

open access: yesCancer, 1952
L J, McCORMACK   +2 more
openaire   +2 more sources

Chemotherapy in Ewing’s sarcoma

open access: yesIndian Journal of Orthopaedics, 2010
Ewing's sarcoma constitutes three per cent of all pediatric malignancies. Ewing's sarcoma has generally been more responsive to chemotherapy than adult-type sarcomas, and chemotherapy is now recommended for all patients with this disease. It is essential to integrate local control measures in the form of surgery and/or radiotherapy at the appropriate ...
Jain, Sandeep, Kapoor, Gauri
openaire   +3 more sources

Primary Ewing sarcoma of the pancreas: A rare extraosseous presentation

open access: yesRadiology Case Reports
Ewing sarcoma is an aggressive neoplasm that is common among children and adolescents, most frequently affecting the pelvis and long bones. Although rare, Ewing sarcoma is known to also occur in extraosseous locations, affecting a broad range of soft ...
Elias Lugo-Fagundo, BS   +3 more
doaj   +1 more source

Neovascularization in Ewing’s sarcoma

open access: yesNeoplasma, 2018
Ewing's sarcoma is the second most common bone malignancy in adolescents and young adults after osteosarcoma. Similar to other solid tumors, Ewing's sarcomas require an adequate vascular supply to grow and survive. The development and maintenance of vascular supply is accomplished via three main mechanisms; angiogenesis, vasculogenesis, and tumor cell ...
Mavrogenis, A.F.   +4 more
openaire   +4 more sources

Ewing Sarcoma of the Kidney, a Rare Entity: Case Report

open access: yesCase Reports in Medicine
Ewing sarcoma is a small round cell tumor of uncertain differentiation, primarily originating in bone in children and adolescents. Ewing sarcoma of the kidney is a rare occurrence and follows an aggressive course with early metastasis. Herein, we present
Alina Baral   +3 more
doaj   +1 more source

Ewing Sarcoma

open access: yesClinical Pediatric Hematology-Oncology, 2019
Ewing sarcoma is the second most frequently occurring malignant tumor of the bone and soft tissue in adolescents and young adults. Genetically, Ewing sarcoma is characterized by balanced chromosomal translocation in which a member of FET gene family is ...
Hee Young Ju
doaj   +1 more source

Suicide gene therapy targeting ewing sarcoma via an ewing-specific GGAA promoter

open access: yesScientific Reports
We recently demonstrated that GGAA promoters (GGAAprom) can be used to drive the expression of therapeutic genes (i.e., Cas9) in vitro and in vivo in a highly specific way in Ewing sarcoma cells.
Saint T. Cervera   +4 more
doaj   +1 more source

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