Results 61 to 70 of about 19,643 (211)

Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma

Neoplasia: An International Journal for Oncology Research, 2019
Ewing sarcoma is a bone tumor most commonly diagnosed in adolescents and young adults. Survival for patients with recurrent or metastatic Ewing sarcoma is dismal and there is a dire need to better understand the mechanisms of cell metastasis specific to ...
Allegra G. Hawkins, Claire M. Julian, Sonja Konzen, Sydney Treichel, Elizabeth R. Lawlor, Kelly M. Bailey   +5 more
doaj   +1 more source

Application of Three‐Dimensionally Printed Surgical Guides in Precise Sacral Tumor Excision and Defect Reconstruction

Orthopaedic Surgery, EarlyView.
Patient‐specific 3D‐printed guiding templates significantly improve surgical precision and efficiency in complex sacral tumor resection and reconstruction compared to conventional freehand techniques. This computer‐assisted workflow reduces operative time, intraoperative blood loss, and fluoroscopy frequency, providing a safer, highly reproducible ...
Yansong Liu, Yinghua He, Huanwen Ding, Hu Chen, Zhongbiao Liang, Ningling Xie, Renxuan Tu, Qiang Tu   +7 more
wiley   +1 more source

Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma.

PLoS ONE
Ewing sarcoma is the second most common bone cancer in children, and while patients who present with metastatic disease at the time of diagnosis have a dismal prognosis.
Ryota Shirai, Tyler Biebighauser, Deandra Walker, Jillian Oviedo, Sarah Nelson-Taylor, Avery Bodlak, Timothy Porfilio, Naoki Oike, Andrew Goodspeed, Masanori Hayashi   +9 more
doaj   +1 more source

Targeting glutathione S-transferase M4 in Ewing sarcoma

Frontiers in Pediatrics, 2014
Ewing sarcoma is a malignant pediatric bone and soft tissue tumor. Although the 5-year survival rate of localized disease approaches 75%, the prognosis of metastatic and/or therapy-resistant disease remains dismal despite the wide use of aggressive ...
Rupeng eZhuo, kenneth ekosak, savita esankar, Elizabeth T Wiles, Ying eSun, Jianxing eZhang, Janet eAyello, Glenn ePrestwich, Paul eShami, Mitchell S Cairo, Stephen eLessnick, Wen eLuo   +11 more
doaj   +1 more source

Parotid gland Ewing Sarcoma in a child – A case report and review of literature

Pediatric Hematology Oncology Journal, 2020
Ewing Sarcoma (ES) is a small round cell tumour of neurectodermal origin commonly seen in the pediatric age group. Uncommon sites of occurence of Ewing sarcoma poses a diagnostic and therapeutic challenge.
M. Jyothi, Anand Prakash, A.M. Shubha
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Salient Features of Mesenchymal Stem Cells – Implications for Ewing Sarcoma Modeling

Frontiers in Oncology, 2013
Despite a heightened appreciation of the many defining molecular aberrations in Ewing sarcoma, the cooperative genetic environment and permissive cell of origin essential for EWS/ETS-mediated oncogenesis remain elusive. Consequently, inducible animal and
Michael James Monument, Nicholas eBernthal, R. Lor eRandall   +2 more
doaj   +1 more source

Reassessing Bone Marrow Aspirate and Trephine Biopsies in Staging for Paediatric and Young Adult Patients With Ewing Sarcoma and Rhabdomyosarcoma

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) are aggressive malignancies in children and adolescents where metastases impact prognosis. 18F‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography (FDG‐PET/CT) and bone marrow aspirate and trephine biopsies (BMAT) are used to identify disease involvement.
Imogen Andrews, Bruce Goodwin, Lauren Buckley, Rick Walker   +3 more
wiley   +1 more source

Ewing Sarcoma of the Spine: Prognostic Variables for Survival and Local Control in Surgically Treated Patients

Global Spine Journal, 2015
Introduction Primary Ewing sarcoma of the spine is a challenging tumor to treat because of a high rate of local recurrence. The optimum role of surgery in the treatment of Ewing sarcoma is not clearly defined.
Laurence Rhines, Michael Dirks, Stefano Boriani, Alessandro Luzzati, Michael Fehlings, Charles Fisher, Mark Dekutoski, Richard Williams, Nasir Quraishi, Ziya Gokaslan, Chetan Bettegowda, Niccole Germscheid, Peter Varga   +12 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source