Results 51 to 60 of about 16,711 (264)

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Conservation du lemur aux yeux turquoise (Eulemur flavifrons)

Revue de Primatologie, 2014
Depuis sa redécouverte en 1985 le lémur aux yeux turquoise a bénéficié de mesures de protection croissantes dans son aire de répartition et de programmes de reproduction en parc zoologique en Amérique du nord, en Europe ainsi qu’à Madagascar.
Brice Lefaux
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Causal Mediation Mechanism of Endogenous Hormones in Seedling Growth Response of Picea abies and Picea crassifolia to Post-Sunset Supplemental Light Durations

Applied Sciences
Post-sunset supplemental light promotes Picea seedling stem elongation, but the underlying hormonal regulation mechanisms on interspecific differences in spruce growth response to photoperiod remain unclear.
Jinping Zhang, Minghui Chen, Yin Cao, Zhihong Niu, Boyang Liu, Fangqun Ouyang, Junhui Wang, Mulualem Tigabu   +7 more
doaj   +1 more source

Unveiling prey preferences of endangered wild Malayan tiger, Panthera tigris jacksoni, in Peninsular Malaysia through scat analysis via COI DNA metabarcoding [PDF]

Nature Conservation
Understanding the prey preference of Malayan tiger (Panthera tigris jacksoni) in Malaysia is important to guide conservation planning initiatives. The utilisation of DNA metabarcoding provides valuable insights, particularly in the field of carnivora ...
Millawati Gani, Frankie Thomas Sitam, Zubaidah Kamarudin, Siti Suzana Selamat, Nik Mohd Zamani Awang, Hani Nabilia Muhd-Sahimi, Michael Wong, Baharim Selat, Nur Fatin Khairunnisa Abdullah-Halim, Lim Shu Yong, Ling Fong Yoke, Salmah Yaakop, Abd Rahman Mohd-Ridwan, Badrul Munir Md-Zain   +13 more
doaj   +3 more sources

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Plant conservation in situ and ex situ in Ukraine

Інтродукція Рослин, 2015
Ukraine is characterized by high diversity of wild flora. Flora of Ukraine is one of the richest in Europe and includes 4523 species of vascular plants. Ukraine occupies 5.7 % of area of Europe and it contains 37 % of European vascular plants. 9 % of species of vascular plants of Ukraine are endemics. There are 611 species of vascular plants in the Red
openaire   +2 more sources

The prevalence of simian malaria in wild long-tailed macaques throughout Peninsular Malaysia

Scientific Reports
The parasite Plasmodium knowlesi has been the sole cause of malaria in Malaysia from 2018 to 2022. The persistence of this zoonotic species has hampered Malaysia’s progress towards achieving the malaria-free status awarded by the World Health ...
Shahhaziq Shahari, Mohd Lutfi Bin Abdullah, Anis Adlina Binti Isman Rohimly, Norsharina Binti Ashrat, Amirah Amir, Wahib Mohammed Mohsen Atroosh, Mun Yik Fong, Yee Ling Lau   +7 more
doaj   +1 more source