Results 81 to 90 of about 16,711 (264)
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Nature Conservation, 2018 The concept of Plant Species with Extremely Small Populations (PSESP) has been employed to guide conservation of threatened plant species in China. Climate change has a high potential to threaten PSESP.
Hong Qu, Chun-Jing Wang, Zhi-Xiang Zhang
doaj +3 more sources
Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang +6 more
wiley +1 more source
Symmetry‐Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies
Advanced Science, EarlyView.A unified group‐theory selection rule governs the excitation of vectorial nearfield topologies across three plasmonic spin states. Derived from first principles, it predicts spin–orbit vortex splitting and multidimensional nested vortices, confirmed by phase‐resolved in situ measurements.
Jie Yang +14 more
wiley +1 more source
BMC GenomicsDNA methylation is important for many developmental processes. Its role in plant’s adaptation to light conditions, however, remains unclear. In this study, we examined the DNA methylomes of Norway spruce (Picea abies (L.) Karst.) under different light ...
Fangqun OuYang +5 more
doaj +1 more source
Advanced Science, EarlyView.A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Parasites & VectorsBackground Plasmodium knowlesi, a non-human primate (NHP) malaria parasite, has become a major public health concern in Malaysia and is now the leading cause of human malaria infections in the country. The transmission of P.
Wei Kit Phang +12 more
doaj +1 more source
Plant CommunicationsUltraviolet-B (UV-B) radiation, a pervasive light stimulus, profoundly influences plant hypocotyl growth through intricate signaling pathways. Although the core UV-B signaling components have been identified, the precise regulatory mechanisms remain ...
Yan Song +18 more
doaj +1 more source