Results 91 to 100 of about 261,950 (315)

Predictive factors for exacerbation and re-exacerbation in chronic obstructive pulmonary disease: an extension of the Cox model to analyze data from the Swiss COPD cohort [PDF]

, 2019
Background The Swiss COPD cohort was established in 2006 to collect data in a primary care setting. The objective of this study was to evaluate possible predictive factors for exacerbation and re-exacerbation.
Sabrina Maier, Kohler, Malcolm, Robert Thurnheer, Bridevaux, Pierre O, Pascal Urwyler, Thomas Geiser, Ladina Joos Zellweger, Leuppi, Joerg D., Dieterle, Thomas, Miedinger, David, Peter Grendelmeier, Abu Hussein, Nebal, Nebal Abu Hussein, Maier, Sabrina, Thomas Dieterle, Prashant N. Chhajed, Leuppi, Joerg D, Tamm, Michael, Michael Tamm, Urwyler, Pascal, Geiser, Thomas, Pierre O. Bridevaux, Joerg D. Leuppi, Malcolm Kohler, Chhajed, Prashant N., Bridevaux, Pierre-Olivier, David Miedinger, Chhajed, Prashant N, Grendelmeier, Peter, Joos Zellweger, Ladina, Bridevaux, Pierre O., Thurnheer, Robert   +31 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute kidney injury in stable COPD and at exacerbation

, 2015
MF Barakat,1 HI McDonald,1 TJ Collier,1 L Smeeth,1 D Nitsch,1 JK Quint1,2 1Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, 2Department of Respiratory Epidemiology, Occupational Medicine and Public Health ...
McDonald HI, Collier TJ, Barakat MF, Nitsch D, Smeeth L, Quint JK   +5 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis

International Journal of COPD, 2016
Claus Vogelmeier,1 Nanshan Zhong,2 Michael J Humphries,3 Karen Mezzi,4 Robert Fogel,5 Giovanni Bader,4 Francesco Patalano,4 Donald Banerji5 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg ...
Vogelmeier C, Zhong NS, Humphries MJ, Mezzi K, Fogel R, Bader G, Patalano F, Banerji D   +7 more
doaj  

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study [PDF]

, 2019
Background: Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study was to determine the frequency of
Kakugawa, Tomoyuki, Ishimatsu, Yuji, Yura, Hirokazu, Tsuchiya, Tomoshi, Okuno, Daisuke, Kido, Takashi, Taniguchi, Daisuke, Obase, Yasushi, Nagayasu, Takeshi, Mukae, Hiroshi, Ishimoto, Hiroshi, Miyazaki, Takuro, Yamaguchi, Hiroyuki, Sakamoto, Noriho, Tsutsui, Shin, Nakashima, Shota, Miyamura, Takuto, Ashizawa, Kazuto   +17 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Incidence and Prognostic Factors of Respiratory Viral Infections in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2021
Jong Geol Jang, June Hong Ahn, Hyun Jung Jin Division of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu, South ...
Jang JG, Ahn JH, Jin HJ
doaj  

The role of airway infection in chronic obstructive pulmonary disease

, 2006
PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core  

The Clinical Characteristics and Outcomes in Non-Frequent Exacerbation Patients with Chronic Obstructive Pulmonary Disease in the Chinese Population

, 2023
Dan Liu,1,* Qing Song,2– 4,* Yuqin Zeng,2– 4 Rong Yi,5 Yi Liu,5 Xin Li,6 Yan Chen,2– 4 Shan Cai,2– 4 Ping Chen2– 4 1Department of Respiratory and Critical Care Medicine, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital),
Liu Y, Li X, Cai S, Chen P, Song Q, Yi R, Chen Y, Zeng Y, Liu D   +8 more
core