Results 91 to 100 of about 283,135 (312)

Triple Therapy with Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate versus Dual Therapies for Patients with COPD and Phenotypic Features of Asthma: A Pooled Post Hoc Analysis of KRONOS and ETHOS

International Journal of COPD
Shigeo Muro,1 Munehiro Seki,2 John R Hurst,3 David Petullo,4 Jonathan Marshall,5 Karin Bowen,4 Patrick F Darken,4 Elizabeth A Duncan,6 Ayman Megally,4 Mehul Patel5 1Department of Respiratory Medicine, Nara Medical University, Nara, Japan; 2AstraZeneca K ...
Muro S, Seki M, Hurst JR, Petullo D, Marshall J, Bowen K, Darken PF, Duncan EA, Megally A, Patel M   +9 more
doaj  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Predictive factors for exacerbation and re-exacerbation in chronic obstructive pulmonary disease: an extension of the Cox model to analyze data from the Swiss COPD cohort [PDF]

, 2019
Background The Swiss COPD cohort was established in 2006 to collect data in a primary care setting. The objective of this study was to evaluate possible predictive factors for exacerbation and re-exacerbation.
Sabrina Maier, Kohler, Malcolm, Robert Thurnheer, Bridevaux, Pierre O, Pascal Urwyler, Thomas Geiser, Ladina Joos Zellweger, Leuppi, Joerg D., Dieterle, Thomas, Miedinger, David, Peter Grendelmeier, Abu Hussein, Nebal, Nebal Abu Hussein, Maier, Sabrina, Thomas Dieterle, Prashant N. Chhajed, Leuppi, Joerg D, Tamm, Michael, Michael Tamm, Urwyler, Pascal, Geiser, Thomas, Pierre O. Bridevaux, Joerg D. Leuppi, Malcolm Kohler, Chhajed, Prashant N., Bridevaux, Pierre-Olivier, David Miedinger, Chhajed, Prashant N, Grendelmeier, Peter, Joos Zellweger, Ladina, Bridevaux, Pierre O., Thurnheer, Robert   +31 more
core   +2 more sources

Clinical Characteristics and Outcomes of Eosinophilic Exacerbations of COPD

International Journal of COPD
Matthew Donnan,1 Tong Lei Liu,1 Matthew Gvalda,1 Xinye Chen,1 Chuan T Foo,1,2 Martin Ian MacDonald,1,2 Francis Thien1,2 1Department of Respiratory Medicine, Eastern Health, Melbourne, Victoria, Australia; 2Faculty of Medicine, Nursing and Health Sciences,
Donnan M, Liu TL, Gvalda M, Chen X, Foo CT, MacDonald MI, Thien F   +6 more
doaj  

Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype

Clinical & Experimental Allergy, 2009
SummaryAsthma is a highly prevalent chronic respiratory disease affecting 300 million people world‐wide. A significant fraction of the cost and morbidity of asthma derives from acute care for asthma exacerbations. In the United States alone, there are approximately 15 million outpatient visits, 2 million emergency room visits, and 500 000 ...
Dougherty, R. H., Fahy, J. V.
openaire   +3 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Continuity of Care Assessment Within a Vertically Integrated Care Management Organization Before and After COPD-Related Exacerbations

International Journal of COPD, 2021
Morgan Justice Fuoco,1 Richard A Mularski,1 Benjamin Wu,2 Chad Moretz,2 Mary Ann McBurnie,1 Richard H Stanford,2 Phillip Crawford,1 Daniel Gratie,2 Bianca Salas1 1Kaiser Permanente Center for Health Research, Science Programs Department, Portland, OR ...
Fuoco MJ, Mularski RA, Wu B, Moretz C, McBurnie MA, Stanford RH, Crawford P, Gratie D, Salas B   +8 more
doaj  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Mometasone/Indacaterol/Glycopyrronium (MF/IND/GLY) and MF/IND at Different MF Strengths versus Fluticasone Propionate/Salmeterol Xinafoate (FLU/SAL) and FLU/SAL+ Tiotropium in Patients with Asthma

Journal of Asthma and Allergy, 2023
Richard N van Zyl-Smit,1 Kenneth R Chapman,2 Huib AM Kerstjens,3 Christian Gessner,4 Hironori Sagara,5 Ana-Maria Tanase,6 Motoi Hosoe,6 Abhijit Pethe,7 David Lawrence,6 Hanns-Christian Tillmann,8 Peter D’Andrea7 1Division of Pulmonology and UCT Lung ...
van Zyl-Smit RN, Chapman KR, Kerstjens HAM, Gessner C, Sagara H, Tanase AM, Hosoe M, Pethe A, Lawrence D, Tillmann HC, D'Andrea P   +10 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source