Results 241 to 250 of about 140,049 (297)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Effectiveness of mepolizumab on mucus plugs and clinical outcomes in severe eosinophilic asthma with and without coexisting bronchiectasis: a prospective pilot study. [PDF]

ERJ Open Res
Campisi R, Nolasco S, Mancuso M, Nardo AA, Intravaia R, Pelaia C, Vancheri C, Crimi N, Crimi C.   +8 more
europepmc   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source

SERPINE1 promoter variants and differential airway responses to virus and biological therapy. [PDF]

J Allergy Clin Immunol
Thames AH, Schutt M, Gadd S, Barrera L, Cho S, Wentworth-Sheilds W, Pongracic J, Liu AH, Gruchalla R, Kercsmar C, Hershey GK, Zoratti E, Johnson C, Teach S, Kattan M, Nodzenski M, Gaberino C, Bacharier L, O'Connor GT, Gern J, Visness C, Coleman A, Gergen P, Becker P, Ober C, Jackson D, Altman M, Kumar R.   +27 more
europepmc   +1 more source

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

COPD Stability and Asthma Remission: Different Words for the Same Therapeutic Ambition? [PDF]

Biomedicines
Carriera L, Mari PV, Lipsi R, Ielo S, De Corso E, Baglioni S, Ricci A, Richeldi L.   +7 more
europepmc   +1 more source

Update on Pediatric asthma management: Recent advances. [PDF]

Pediatr Allergy Immunol
Dhochak N, Robinson PFM, Saglani S.
europepmc   +1 more source

Risk factors and prediction model for chronic bacterial infection in stable bronchiectasis in Shanghai, China. [PDF]

Front Med (Lausanne)
Chen Y, Zhang S, Su B, Zhou R, Chen T, Xu X, Zhang Z, Wu D, Lu Z, Qiu L.   +9 more
europepmc   +1 more source

Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial. [PDF]

EClinicalMedicine
Zielen S, Wollscheid N, Nickolay T, Grimmel C, Scheele D, Sattler F, Prenzel F, Lorenz M, Schaub B, Lex C, Stieglitz F, Trischler J, Donath H, Lau S, Hamelmann E, Vogelberg C, Gerstlauer M, Grychtol R, Schubert R, Gappa M, Schollenberger L, Wosniok J.   +21 more
europepmc   +1 more source

Clinical Meaningfulness of the Composite Endpoint, COPDCompEx, in Defining Exacerbations and Worsening of COPD: A Post Hoc Analysis of 4 Clinical Interventional Studies of COPD. [PDF]

Int J Chron Obstruct Pulmon Dis
Tal-Singer R, Vogelmeier CF, Bolton C, Bengtsson T, Peterson S, Sidaway M, Da Silva CA.   +6 more
europepmc   +1 more source