Results 91 to 100 of about 892,017 (284)
PairMotif: A new pattern-driven algorithm for planted (l, d) DNA motif search.
PLoS ONE, 2012 Motif search is a fundamental problem in bioinformatics with an important application in locating transcription factor binding sites (TFBSs) in DNA sequences.
Qiang Yu +3 more
doaj +1 more source
Generating and Sampling Orbits for Lifted Probabilistic Inference [PDF]
, 2019 A key goal in the design of probabilistic inference algorithms is identifying and exploiting properties of the distribution that make inference tractable.
Broeck, Guy Van den +2 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Exact algorithms for solving a bi-level location–allocation problem considering customer preferences
Journal of Industrial Engineering International, 2019 The issue discussed in this paper is a bi-level problem in which two rivals compete in attracting customers and maximizing their profits which means that competitors competing for market share must compete in the centers that are going to be located in ...
Ehsan Mirzaei +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Revista Colombiana de Estadística, 2014 AP-design, an efficient non-rejective implementation of the πps sampling design, was proposed in the literature as an alternative Poisson sampling scheme. In this paper, we have updated inclusion probabilities formulas in the AP sampling design.
ZAIZAI YAN, YUXIA XUE
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
EURO Journal on Computational Optimization, 2017 The generalized directed rural postman problem is an arc routing problem with many interesting real-life applications, such as routing for meter reading. In this application, a vehicle with a receiver travels through a series of neighborhoods.
Thais Ávila +3 more
doaj +1 more source
Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz +25 more
wiley +1 more source