Multinomial goodness-of-fit: large sample tests with survey design correction and exact tests for small samples [PDF]
A new Stata command called -mgof- is introduced. The command is used to compute distributional tests for discrete (categorical, multinomial) variables. Apart from classic large sample $\chi^2$-approximation tests based on Pearson's $X^2$, the likelihood ...
Ben Jann
core
Improvements and comparison of heuristics for solving the uncapacitated multisource Weber problem [PDF]
Copyright @ 2000 INFORMSThe multisource Weber problem is to locate simultaneously m facilities in the Euclidean plane to minimize the total transportation cost for satisfying the demand of n fixed users, each supplied from its closest facility.
Taillard, ED +7 more
core +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
An Algorithm for the Exact Treedepth Problem
14 pages, 6 figures, 2 tables. This is an extended version of a paper to appear in the proceedings of SEA 2020. The arXiv version is the conference version plus Appendix A (a correctness proof)
openaire +5 more sources
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
exact-real is a C++/Python library which provides exact lazy computations in the Real Numbers. In particular it implements arithmetic and comparisons of (random) transcendental numbers.Please visit our home page for more ...
Rüth, Julian
core +1 more source
Superlinear advantage for exact quantum algorithms [PDF]
A quantum algorithm is exact if, on any input data, it outputs the correct answer with certainty (probability 1). A key question is: how big is the advantage of exact quantum algorithms over their classical counterparts: deterministic algorithms. For total Boolean functions in the query model, the biggest known gap was just a factor of 2: PARITY of N ...
openaire +4 more sources
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source

