Results 41 to 50 of about 3,795 (264)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Controllability results for weakly blowing up reaction-diffusion system

Electronic Journal of Qualitative Theory of Differential Equations, 2012
In this paper, we consider the controllability of a general reaction-diffusion system with homogeneous Dirichlet boundary conditions. We prove the exact controllability to the trajectories and the approximate controllability of the system which contains ...
Qiang Tao, Hang Gao, Ying Yang
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Investigation on the Controllability of Semilinear Integrodifferential Fractional Stochastic Control System in Conformable Sense With Impulses

Journal of Mathematics
Controllability concepts have been essential across various disciplines, including control theory, engineering, and applied mathematics. According to Kalman’s definition, controllability points to the capacity to move a control system’s solution from any
Maher Jneid
doaj   +1 more source

The Exact Controllability of the Molecular Graph Networks

Journal of Chemistry, 2019
In this paper, we mainly study the exact controllability of several types of extended-path molecular graph networks. Based on the construction of extended-path molecular graph networks with C3, C4, or K4, using the determinant operation of the matrix and
Liang Wei, Faxu Li, Haixing Zhao, Bo Deng, Zhonglin Ye   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Exact controllability for nonlocal semilinear differential inclusions

Bruno Pini Mathematical Analysis Seminar
In this paper, we investigate the controllability of a class of semilinear differential inclusions in Hilbert spaces. Assuming the exact controllability of the associated linear problem, we establish sufficient conditions for achieving the exact ...
Irene Benedetti, Angelica Palazzoni
doaj   +1 more source

Exact Controllability for Wave Equations with Switching Controls

Taiwanese Journal of Mathematics, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source