Results 71 to 80 of about 784,928 (256)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

On the posterior distribution of classes of random means [PDF]

The study of properties of mean functionals of random probability measures is an important area of research in the theory of Bayesian nonparametric statistics.
Antonio Lijoi, Igor Prünster, Lancelot F. James   +2 more
core  

Evidence for geometry-dependent universal fluctuations of the Kardar-Parisi-Zhang interfaces in liquid-crystal turbulence

, 2012
We provide a comprehensive report on scale-invariant fluctuations of growing interfaces in liquid-crystal turbulence, for which we recently found evidence that they belong to the Kardar-Parisi-Zhang (KPZ) universality class for 1+1 dimensions [Phys. Rev.
A. Borodin, A. Borodin, A.L. Barabasi, C. Tracy, C.A. Tracy, C.A. Tracy, D. Forster, D.T. Gillespie, E.J. Gumbel, E.W. Kuennen, F. Bornemann, F. Bornemann, F. Family, G. Amir, G.F. Newell, H. Hinrichsen, H. Kallabis, H.E. Stanley, I. Corwin, I. Corwin, J. Baik, J. Baik, J. Baik, J. Baik, J. Krug, J. Krug, J. Krug, J. Krug, J. Maunuksela, J. Merikoski, J. Rambeau, J. Rambeau, J. Rodríguez-Laguna, J.G. Amar, J.i. Wakita, K. Johansson, K. Johansson, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, Kazumasa A. Takeuchi, L. Canet, L. Canet, L. Miettinen, L.R. Paiva, M. Clusel, M. Constantin, M. Henkel, M. Henkel, M. Kardar, M. Myllys, M. Myllys, M. Mézard, M. Prähofer, M. Prähofer, M. Prähofer, M.A.C. Huergo, M.A.C. Huergo, M.L. Mehta, Masaki Sano, P. Calabrese, P. Calabrese, P. Meakin, P.G. Gennes de, P.J. Forrester, P.L. Ferrari, P.L. Ferrari, P.L. Ferrari, S. Kai, S. Kai, S. Prolhac, S. Prolhac, S.B. Singha, S.C. Ferreira Jr, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, T. Halpin-Healy, T. Kriecherbauer, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Vicsek, T.E. Harris, T.J. Oliveira, U. Frisch, V. Dotsenko   +91 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

How fast does a random walk cover a torus?

, 2017
We present high statistics simulation data for the average time $\langle T_{\rm cover}(L)\rangle$ that a random walk needs to cover completely a 2-dimensional torus of size $L\times L$. They confirm the mathematical prediction that $\langle T_{\rm cover}(
Grassberger, Peter
core   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source