Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Distribution of the product of a pair of independent two-sided power variates [PDF]
, 2016 : The distributions of algebraic functions of random variables are important in theory of probability and statistics and other areas such as engineering, reliability, and actuarial applications, and many results based on various distributions are ...
Selim Gündüz +3 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Inference under progressively type II right censored sampling for certain lifetime distributions [PDF]
, 2009 In this paper, estimation of the parameters of a certain family of two-parameter lifetime distributions based on progressively Type II right censored samples (including ordinary Type II right censoring) is studied.
Yu, K, Wang, BX, Jones, MC
core
Health Technology AssessmentBackground Community-based optometrists, a major provider of primary eye care in the United Kingdom, are the main source of referrals to hospital eye services.
Anitta Sharma +22 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Assessing Instrumental Variable Relevance:An Alternative Measure and Some Exact Finite Sample Theory [PDF]
focus on the ability of the instrument set to predict a single endogenous regressor, even if there is more than one endogenous regressor in the equation of interest.
C.L. Skeels, D.S. Poskitt
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Exact Cumulative Distribution Function of a Ratio of Quadratic Forms in Normal Variables with Application to the AR(1) Model. [PDF]
Often neither the exact density nor the exact cumulative distribution function (CDF) of a statistic of interest are available in the statistics and econometrics literature (for example the maximum likelihood estimator of the autocorrelation coefficient ...
Giovanni Forchini
core
Optimal Parameter Estimation of the Extreme Value Distribution Based on a Type II Censored Sample [PDF]
, 2009 Different types of exact confidence intervals and exact joint confidence regions for the parameters of the Type I extreme value distribution based on a doubly Type II censored sample or a right censored sample are developed in this paper.
吳忠武; Wu, J. W.; 李百靈; Li, Pai-ling
core +1 more source