Results 71 to 80 of about 785,845 (222)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Evidence for geometry-dependent universal fluctuations of the Kardar-Parisi-Zhang interfaces in liquid-crystal turbulence

, 2012
We provide a comprehensive report on scale-invariant fluctuations of growing interfaces in liquid-crystal turbulence, for which we recently found evidence that they belong to the Kardar-Parisi-Zhang (KPZ) universality class for 1+1 dimensions [Phys. Rev.
A. Borodin, A. Borodin, A.L. Barabasi, C. Tracy, C.A. Tracy, C.A. Tracy, D. Forster, D.T. Gillespie, E.J. Gumbel, E.W. Kuennen, F. Bornemann, F. Bornemann, F. Family, G. Amir, G.F. Newell, H. Hinrichsen, H. Kallabis, H.E. Stanley, I. Corwin, I. Corwin, J. Baik, J. Baik, J. Baik, J. Baik, J. Krug, J. Krug, J. Krug, J. Krug, J. Maunuksela, J. Merikoski, J. Rambeau, J. Rambeau, J. Rodríguez-Laguna, J.G. Amar, J.i. Wakita, K. Johansson, K. Johansson, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, K.A. Takeuchi, Kazumasa A. Takeuchi, L. Canet, L. Canet, L. Miettinen, L.R. Paiva, M. Clusel, M. Constantin, M. Henkel, M. Henkel, M. Kardar, M. Myllys, M. Myllys, M. Mézard, M. Prähofer, M. Prähofer, M. Prähofer, M.A.C. Huergo, M.A.C. Huergo, M.L. Mehta, Masaki Sano, P. Calabrese, P. Calabrese, P. Meakin, P.G. Gennes de, P.J. Forrester, P.L. Ferrari, P.L. Ferrari, P.L. Ferrari, S. Kai, S. Kai, S. Prolhac, S. Prolhac, S.B. Singha, S.C. Ferreira Jr, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, T. Halpin-Healy, T. Kriecherbauer, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Sasamoto, T. Vicsek, T.E. Harris, T.J. Oliveira, U. Frisch, V. Dotsenko   +91 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Review of the Maximum Likelihood Functions for Right Censored Data. A New Elementary Derivation. [PDF]

, 2007
Censoring is a well known feature recurrent in the analysis of lifetime data, occurring in the model when exact lifetimes can be collected for only a representative portion of the surveyed individuals.
Biganzoli, Elia, Boracchi, Patrizia, Patti, Stefano   +2 more
core   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Credibility Approximations for Bayesian Prediction of Second Moments [PDF]

, 2017
Credibility theory refers to the use of linear least-squares theory to approximate the Bayesian forecast of the mean of a future observation; families are known where the credibility formula is exact Bayesian. Second-moment forecasts are also of interest,
Schnieper, Rene, William, S. Jewell,
core  

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source