Results 181 to 190 of about 7,967,850 (308)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Comparative Performance of Large Language Models on European Gastroenterology Board-Style Questions: Analysis of Reasoning Versus Non-Reasoning Architectures. [PDF]

J Clin Med
Simsek C, Vanek P, Aydinli H, Krivinka J, Lehner M, Schiavone S, Hassan C, Heinrich HH.   +7 more
europepmc   +1 more source

Review of Health Examination Surveys in Europe. [PDF]

, 2008
Aromaa, A, Conti, S, et, A, Graff-Iversen, S, Grøtvedt, L, Kanieff, M, Koponen, P, Mindell, J, Tolonen, H   +8 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Atypical chronic lymphocytic leukemia with biallelic 13Q deletion. [PDF]

Hematol Transfus Cell Ther
Roldán Galiacho V, Altuna Tellechea L, Alonso Varela M, Diez de Lezcano Manrique deLara I.   +3 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Performance of DeepSeek V3, DeepSeek R1, ChatGPT 4o, and ChatGPT o1 on the National Health Professional and Technical Qualification Examination (Intermediate Level) in China: Comparative Analysis. [PDF]

JMIR Form Res
Xue J, Wang S, Yang J, Guo X, Shen J, Wang Q.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Accuracy of Visual Inspection Alone to Assess Joint Effusions of the Hand: Cross-Sectional Study.

J Med Internet Res
Ye C, Mitchell JR, Al-Matar S, Bishay M, Jones N, Sholter D, Johnson D, Katz S, Russell AS, Abdalla M.   +9 more
europepmc   +1 more source

Abnormal pupils at the bedside: rapid recognition of neurologic and systemic emergencies in acute care settings. [PDF]

Int J Emerg Med
Penney DC, Rushetsky ZM, Penney DW.
europepmc   +1 more source