Results 91 to 100 of about 339,132 (339)

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

open access: yesAdvanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang   +7 more
wiley   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

open access: yesAdvanced Science, EarlyView.
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu   +13 more
wiley   +1 more source

Analysis of Deformation of Deep and Large Foundation Pit Support Structure and Impact on Neighbouring Buildings in Complex Environments

open access: yesBuildings
The development trend of urban underground space towards deep and large three-dimensional foundation pit projects in complex environments faces the challenges of deformation and instability of supporting structures, strong sensitivity of the surrounding ...
Chao Guo   +3 more
doaj   +1 more source

Conceptual design of equipment to excavate and transport regolith from the lunar maria [PDF]

open access: yes
NASA hopes to have a manned lunar outpost completed by 2005. In order to establish the base, regolith must be excavated from the lunar surface. Regolith will be used as a source for life-supporting elements and as radiation shielding for the lunar ...
Detwiler, Mark   +2 more
core   +1 more source

Implementation of probabilistic approach to rock mass strength estimation while excavating through fault zones [PDF]

open access: yes, 2019
Purpose. The paper addresses the rock mass state estimation while excavating a cross-heading through the area of regional fault “Bohdanivskyi” based on probabilistic approach to assessing the rock strength. Methods.
Babets, D   +4 more
core   +1 more source

Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity

open access: yesAdvanced Science, EarlyView.
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang   +10 more
wiley   +1 more source

First-year nest growth in the leaf-cutting ants Atta bisphaerica and Atta sexdens rubropilosa

open access: yesSociobiology, 2014
The majority of ants construct nests underground to maintain environmental conditions favorable to the development of immature and adult individuals. But little is known about nest growth.
Sandra Cardoso   +3 more
doaj   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

open access: yesAdvanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin   +7 more
wiley   +1 more source

Root System Reductions of Grafted ‘Valencia’ Orange Trees Are More Extensive Than Aboveground Reductions after Natural Infection with Candidatus Liberibacter Asiaticus

open access: yesHortScience
Huanglongbing (HLB), which is associated with the phloem-limited bacteria Candidatus Liberibacter asiaticus (CLas), is a devastating disease that affects citrus trees worldwide. Because of the pervasiveness of the bacteria and psyllid vector, the disease
Caroline Tardivo   +4 more
doaj   +1 more source

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