Results 91 to 100 of about 339,132 (339)
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang+7 more
wiley +1 more source
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu+13 more
wiley +1 more source
The development trend of urban underground space towards deep and large three-dimensional foundation pit projects in complex environments faces the challenges of deformation and instability of supporting structures, strong sensitivity of the surrounding ...
Chao Guo+3 more
doaj +1 more source
Conceptual design of equipment to excavate and transport regolith from the lunar maria [PDF]
NASA hopes to have a manned lunar outpost completed by 2005. In order to establish the base, regolith must be excavated from the lunar surface. Regolith will be used as a source for life-supporting elements and as radiation shielding for the lunar ...
Detwiler, Mark+2 more
core +1 more source
Implementation of probabilistic approach to rock mass strength estimation while excavating through fault zones [PDF]
Purpose. The paper addresses the rock mass state estimation while excavating a cross-heading through the area of regional fault “Bohdanivskyi” based on probabilistic approach to assessing the rock strength. Methods.
Babets, D+4 more
core +1 more source
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang+10 more
wiley +1 more source
First-year nest growth in the leaf-cutting ants Atta bisphaerica and Atta sexdens rubropilosa
The majority of ants construct nests underground to maintain environmental conditions favorable to the development of immature and adult individuals. But little is known about nest growth.
Sandra Cardoso+3 more
doaj +1 more source
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin+7 more
wiley +1 more source
Huanglongbing (HLB), which is associated with the phloem-limited bacteria Candidatus Liberibacter asiaticus (CLas), is a devastating disease that affects citrus trees worldwide. Because of the pervasiveness of the bacteria and psyllid vector, the disease
Caroline Tardivo+4 more
doaj +1 more source