Results 81 to 90 of about 361,466 (347)

TBM pressure models: observations, theory and practice [PDF]

, 2015
Mechanized tunnelling in soft ground has evolved significantly over the last 20 years. However, the interaction between the tunnel boring machine (TBM) and the ground is often understood through idealized concepts, focused mostly on the machine actions ...
Bezuijen, Adam, Gerheim Souza Dias, Tiago   +1 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Discovery of candidate genes involved in ethylene biosynthesis and signal transduction pathways related to peach bud cold resistance

Frontiers in Genetics
Background: Low temperature pose significant challenges to peach cultivation, causing severe damage to peach buds and restricting production and distribution.
Wenqian Xia, Yupeng Yang, Chenguang Zhang, Chenguang Zhang, Chunsheng Liu, Chunsheng Liu, Kun Xiao, Kun Xiao, Xiao Xiao, Xiao Xiao, Junkai Wu, Junkai Wu, Yanhong Shen, Yanhong Shen, Libin Zhang, Libin Zhang, Libin Zhang, Kai Su, Kai Su, Kai Su   +19 more
doaj   +1 more source

Chemical Enhancement of Bloody Footwear Impressions from Buried Substrates [PDF]

, 2010
Footwear impressions are regarded as one of the most common forensic evidence types left at crime scenes. A review of research to date describes previous tests on the survival of footwear impressions in a range of contaminants on a myriad of surfaces ...
Cheetham, Paul, Cullen, Siobhan, Otto, Alexandra   +2 more
core  

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Conceptual design of equipment to excavate and transport regolith from the lunar maria [PDF]

NASA hopes to have a manned lunar outpost completed by 2005. In order to establish the base, regolith must be excavated from the lunar surface. Regolith will be used as a source for life-supporting elements and as radiation shielding for the lunar ...
Detwiler, Mark, Foong, Chee Seng, Stocklin, Catherine   +2 more
core   +1 more source

Fault slip in a mining context [PDF]

, 2004
Recent articles on the broad range of computational and analytic techniques currently used to investigate excavation collapse are reported. Advances in physical models are also described.
Fowkes, N.D., Mason, D.P., Napier, J.A.L.   +2 more
core  

Relationships between the Mandibles, Feeding Behavior, and Damage Inflicted on Plants by the Feeding of Certain Acridids (Orthoptera) [PDF]

, 2017
[excerpt] In 1960 the author described three fundamental patterns of feed- ing in Orthoptera and their allies and emphasized the close correlation that exists between the insects\u27 mouthpart structure, food, and feeding pattern. An article by Anderson (
Gangwere, S. K.
core   +3 more sources

Multimodal Retinal Imaging of Paediatric Focal Choroidal Excavations [PDF]

, 2023
Kevin R. Clarke, K Mahgoubn, Katarina Hurtikova, Dhanes Thomas   +3 more
openalex   +1 more source