Results 61 to 70 of about 34,330 (267)

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Discovery of candidate genes involved in ethylene biosynthesis and signal transduction pathways related to peach bud cold resistance

Frontiers in Genetics
Background: Low temperature pose significant challenges to peach cultivation, causing severe damage to peach buds and restricting production and distribution.
Wenqian Xia, Yupeng Yang, Chenguang Zhang, Chenguang Zhang, Chunsheng Liu, Chunsheng Liu, Kun Xiao, Kun Xiao, Xiao Xiao, Xiao Xiao, Junkai Wu, Junkai Wu, Yanhong Shen, Yanhong Shen, Libin Zhang, Libin Zhang, Libin Zhang, Kai Su, Kai Su, Kai Su   +19 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Too Complex to Choose? The Role of Heuristics in Shaping Farmers' Willingness to Pay for Income Stabilization Tool in Italy

Agribusiness, EarlyView.
ABSTRACT European agriculture is increasingly exposed to economic instability driven by extreme weather events, market volatility, and geopolitical tensions. To manage these growing risks, farmers are encouraged to adopt innovative risk management strategies such as the Income Stabilization Tool (IST), which offers protection against severe income ...
Alice Stiletto, Ruggiero Rippo, Samuele Trestini, Elisa Giampietri, Roberta Raffaelli, Simone Cerroni   +5 more
wiley   +1 more source

Hemiparasitic Castilleja presence is correlated with increased plant biodiversity across montane plant communities

American Journal of Botany, EarlyView.
Abstract Premise Root hemiparasites form haustoria in belowground roots of hosts to extract nutrients and water from the surrounding hosts. Through parasitic symbiosis, these plants disproportionately affect plant communities relative to their abundance by reducing host size, altering nutrient flow, and eventually increasing local biodiversity.
Jordan C. Argrett, Makena Lang, Anders Hastings, Y. Anny Chung, Nina Wurzburger, Charles F. Williams   +5 more
wiley   +1 more source

Yurta‑Stroyno Archaeological Project. Preliminary Report to the Final Season of 2016 [PDF]

Studia Hercynia, 2017
The last field season of the Yurta‑Stroyno Archaeological Project conducted in 2016 focused on finishing the excavation of the five‑room house previously discovered in the southern part of the Roman settlement.
Petra Tušlová, Barbora Weissová, Stefan Bakardzhiev   +2 more
doaj  

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo, Barbara Iazzolino, Cristina Moglia, Umberto Manera, Enrico Matteoni, Sara Cabras, Giorgio Pellegrino, Emilio Minerva, Vita Passidomo, Rosario Vasta, Gabriele Mora, Fabrizio D’Ovidio, Antonio Canosa, Andrea Calvo, Adriano Chiò   +14 more
wiley   +1 more source

MdHSFA2 enhances heat stress tolerance through promoting the MdGolS4 transcription in apple

Scientific Reports
With global climate change, extremely high temperatures are occurring frequently during summer, seriously affecting development of the apple industry.
Mohan Li, Xiaoshuang Zhang, Dongliang Zuo, Junkai Wu, Libin Zhang, Xiao Xiao, Libo Xing, Chenguang Zhang   +7 more
doaj   +1 more source