Results 51 to 60 of about 34,036 (268)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon   +21 more
wiley   +1 more source

(Pre) Iron Age Burials of Thandikudi, Tamil Nadu

open access: yesAncient Asia, 2015
Thandikudi, one of the major villages in the Lower Palani Hills occupies a unique position as this village was well connected by major trade routes. The archaeological vestiges unearthed here have clearly attested that it was
RaNa Kumaran, M Saranya
doaj   +1 more source

Terrassements sur terrains marneux sensibles aux glissements : cas des terrains et remblais autoroutiers entre Oued Amlil et Taza (Rif, Maroc)

open access: yesPhysio-Géo, 2015
In north of Morocco, between Oued Amlil and Taza, the Fes-Oujda highway alignment crosses the Rif's overlap front of the thrust covering the Middle Atlas. This Prerif and South Rif corridor area has a lithology dominated by Upper Miocene's marls.
Mohamed Mouhssine   +3 more
doaj   +1 more source

The 2020 Re-Excavation of Callao Cave, Northeastern Luzon, the Philippines | Ang Muling Pagsusuring Archaeological sa Callao Cave, Hilagang-Silangang Luzon, Pilipinas sa 2020

open access: yesSPAFA Journal, 2020
This article provides a first-person perspective on the experiences of the archaeologists who re-excavated Callao Cave in Cagayan Province, Northeastern Luzon, Philippines.
Kathleen D. Tantuico
doaj   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

open access: yesAdvanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu   +11 more
wiley   +1 more source

Equipment Combination Model for Effective Excavation Work for Urban High Rise Buildings

open access: yesJournal of Asian Architecture and Building Engineering, 2017
The excavation work for constructing urban high-rise buildings is narrow and deep, limiting the mobility of equipment. In addition, the productivity of excavation work varies according to the type and amount of equipment used. Therefore, a combination of
Donghoon Lee, Jun-Young Park, Sunkuk Kim
doaj   +1 more source

Towards Learning Boulder Excavation with Hydraulic Excavators

open access: yesCoRR
Construction sites frequently require removing large rocks before excavation or grading can proceed. Human operators typically extract these boulders using only standard digging buckets, avoiding time-consuming tool changes to specialized grippers. This task demands manipulating irregular objects with unknown geometries in harsh outdoor environments ...
Jonas Gruetter   +3 more
openaire   +2 more sources

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

open access: yesAdvanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li   +9 more
wiley   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

open access: yesAdvanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu   +11 more
wiley   +1 more source

Greenhouse Gas Emissions from Excavation on Residential Construction Sites

open access: yesConstruction Economics and Building, 2014
Despite considerable research concerning the manifestation of greenhouse gases in the usage of buildings, little has been done concerning emissions arising from the construction process itself.
Perry Forsythe, Grace Ding
doaj   +1 more source

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