Results 81 to 90 of about 465,954 (329)

The microstratigraphy of middens: capturing daily routine in rubbish at Neolithic Çatalhöyük, Turkey [PDF]

open access: yes, 2011
Microstratigraphy — the sequencing of detailed biological signals on site — is an important new approach being developed in the Çatalhöyük project. Here the authors show how microscopic recording of the strata and content of widespread middens on the ...
Almond, Matthew J.   +3 more
core   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen   +12 more
wiley   +1 more source

Archeological Investigations on the Weyerhaeuser Land Exchange Sites, McCurtain County, Oklahoma: An Update [PDF]

open access: yes, 2001
This paper provides a brief overview of the testing work completed to date on sites within the Tiak Ranger District. Ouachita National Forest. McCurtain County, Oklahoma.
Etchieson, Meeks
core   +1 more source

Arguments for a "U.S. Kamioka": SNOLab and its Implications for North American Underground Science Planning [PDF]

open access: yes, 2006
We argue for a cost-effective, long-term North American underground science strategy based on partnership with Canada and initial construction of a modest U.S. Stage I laboratory designed to complement SNOLab.
Aalseth   +22 more
core   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

Vlog to Death: Project Eliseg's Video-Blogging

open access: yesInternet Archaeology, 2015
Project Eliseg involved three field seasons (2010–12) of survey and excavation at the multi-period mortuary and commemorative monument known as the Pillar of Eliseg, near Llangollen, Denbighshire, Wales.
Joseph Tong   +4 more
doaj   +1 more source

Coupled THM analysis of long-term anisotropic convergence in the full-scale micro tunnel excavated in the Callovo-Oxfordian argillite [PDF]

open access: yes, 2019
The main purpose of this paper is to analyse the convergence measurements of the ALC1604 in situ heating test carried out in the Callovo-Oxfordian claystone formation (COx) in the Meuse/Haute-Marne underground research laboratory (MHM URL).
Bumbieler, F.   +4 more
core   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

open access: yesAdvanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu   +12 more
wiley   +1 more source

Kumukumu 1, a hilltop site in the Aird Hills: Implications for occupational trends and dynamics in the Kikori River delta, south coast of Papua New Guinea [PDF]

open access: yes, 2014
We report on archaeological excavations undertaken at Kumukumu 1 atop the dense rainforest-clad Aird Hills of the Kikori river delta islands, south coast of Papua New Guinea.
Aplin, Ken   +8 more
core   +3 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

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