Results 121 to 130 of about 47,744 (298)

The Theory of Necessity and Exceptional Circumstances as an Exception to Void and Null Administrative Decisions

International Journal of Religion
The theory of exceptional circumstances is one of the important and complex theories in contemporary administrative thought, and this theory finds its basis in Islamic Sharia before being recognized by positive laws, where the fundamental pillar of Islamic Sharia is justice, fairness, and the protection of rights.
Khalid Ali Y. Alshahrani, Abdulrahman Ahmad N. Alhathi, Ali Muhammad Muhammad Al-Darwbi   +2 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

“No decisions about us without us”? Individual healthcare rationing decisions in a fiscal ice age

, 2011
Jill Russell and colleagues examine whether patients and the public should be involved in rationing decisions about individual patient access to healthcare ...
A. Burnett, J. Montgomery, Montgomery, J, Burnett, Andrew, Greenhalgh, T, T. Greenhalgh, Russell, Jill, Greenhalgh, Tricia, Russell, J, J. Russell, Montgomery, Jonathan, Burnett, A   +11 more
core   +1 more source

Audit of Child and Adolescent Admissions to an Adult Psychiatric Unit: Addressing Service Gaps and Legal Compliance

BJPsych Open
Aims: Guidance from the Mental Welfare Commission for Scotland (2013) and the Scottish Government’s Best Practice Guideline for Admission to Adult Mental Health Wards for Under 18s (2013) states that young people should be admitted to age-appropriate ...
Praveen Kumar, Kevin Edassery, Parth Dhirawani, Soma Tadi   +3 more
doaj   +1 more source

The Impact of the Economic Corridor on Economic Stability: A Double Mediating Role of Environmental Sustainability and Sustainable Development Under the Exceptional Circumstances of COVID-19. [PDF]

Front Psychol, 2020
Li H, Hameed J, Khuhro RA, Albasher G, Alqahtani W, Sadiq MW, Wu T.   +6 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Conditional Approval and Approval Under Exceptional Circumstances as Regulatory Instruments for Stimulating Responsible Drug Innovation in Europe

, 2010
The need for fast drug innovation and the public demand for risk-free drugs creates a dilemma for regulatory authorities: less restrictive procedures involve uncertainties about benefit/risk profiles of new drugs.
Schellekens, H., W P C Boon, Boon, W.P.C., H Schellekens, Boon, W. P C, E H M Moors, Moors, E.H.M., Meijer, A., Moors, E. H M, A Meijer   +9 more
core   +1 more source

Exceptional Circumstances of the Iraqi Constitution of 2005

The International and Political Journal
The balance of power between states of emergency and human rights is a challenge in the Middle East, with Iraq being a prominent example. Historically, governments have used states of emergency to suppress opposition, resulting in widespread human rights violations.
openaire   +1 more source