Results 91 to 100 of about 667,199 (276)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Feature analysis aided design of lightweight heat sink from network structures

iScience
Summary: The advent of electronic devices has revolutionized engineering applications and fundamentally transformed society. However, their lifespan is significantly impacted by operational temperatures, as excess heat can elevate localized temperatures (
Tianlin Luo, Changliang Zhu, Baowen Li, Xiangying Shen, Guimei Zhu   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

What controls thermo-osmosis? Molecular simulations show the critical role of interfacial hydrodynamics

, 2017
Thermo-osmotic and related thermo-phoretic phenomena can be found in many situations from biology to colloid science, but the underlying molecular mechanisms remain largely unexplored.
Fu, Li, Joly, Laurent, Merabia, Samy
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Characterizing adaptive capacity for the future heat-related cardiovascular morbidity burden in U.S. Metropolitan areas

Environment International
Exposure to excess heat is linked to increased risks of cardiovascular diseases (CVD). As temperatures increase globally, it is crucial to examine the potential increase in excess heat-related CVD (xHEAT-CVD) burden to inform strategies for adaptation ...
Wei-Lun Tsai, E.Melissa Mcinroe, Anna M. Jalowska, Corinna Y. Keeler, Stephanie E. Cleland, Cassandra R. O’Lenick, Tanya L. Spero, Alexandra Schneider, Ana G. Rappold   +8 more
doaj   +1 more source

Experimental verification of suitability of insulation testing rig in determining thermophysical properties of insulating materials

Cogent Engineering, 2019
Verification of suitability of insulation testing rig (ITR) in determining the thermophysical properties of insulating materials (IM) is strongly based on the measurement of temperatures on the inner/outer surfaces of the insulators (white cotton fabric,
S. N. Nnamchi, O. A. Nnamchi, O. S. Odebiyi, O. O. Edosa, T. Wanazusi   +4 more
doaj   +1 more source

Results from phase 1 of the HAYSTAC microwave cavity axion experiment

, 2018
We report on the results from a search for dark matter axions with the HAYSTAC experiment using a microwave cavity detector at frequencies between 5.6-5.8$\, \rm Ghz$.
Backes, K. M., Brubaker, B. M., Cahn, S. B., Carosi, G., Gurevich, Y. V., Kenany, S. Al, Kindel, W. F., Lamoreaux, S. K., Lehnert, K. W., Lewis, S. M., Malnou, M., Maruyama, R. H., Palken, D. A., Rapidis, N. M., Root, J. R., Shokair, T. M., Simanovskaia, M., Speller, D. H., Urdinaran, I., van Bibber, K. A., Zhong, L.   +20 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Influence of initial binary mixture state of matter on heat costs at rectification

Тонкие химические технологии, 2014
Analysis of heat cost for rectification was performed taking into account the phase state of the original mixture. It was proved theoretically that increasing feed vapor fraction leads to decreasing energy consumption in conventional distillation process.
M. K. Zakharov, Mohand Abbasi
doaj