Results 31 to 40 of about 34,548 (260)

Experimental Investigation of Pore Pressure on Sandy Seabed around Submarine Pipeline under Irregular Wave Loading

Sensors
The propagation of shallow-water waves may cause liquefaction of the seabed, thereby reducing its support capacity for pipelines and potentially leading to pipeline settlement or deformation.
Changjing Fu, Jinguo Wang, Tianlong Zhao
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Experimental Study on the Uplift Correction of Raft Foundations in Saturated Silty Clay

Buildings
Although grouting technology has been widely applied for lifting and rectifying tilted structures, theoretical research remains underdeveloped and lags behind the practical demands of engineering applications. In this study, a self-developed experimental
Tengyue Cui, Yingguang Shi, Feng Huang
doaj   +1 more source

Field Test Investigation of the Pile Jacking Performance for Prefabricated Square Rigid-Drainage Piles in Saturated Silt Sandy Soils

Advances in Civil Engineering, 2019
The rigid-drainage pile, designed to accelerate the dissipation of excess pore water pressure around the pile, is a new type of pile that combines the bearing capacity of ordinary rigid piles and the draining capacity of gravel piles.
Xiangying Wang
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental investigation on reinforcement and deformation control of soft clay using capsule expansion combined with electro-osmosis method

Yantu gongcheng xuebao
Grouting in soft clay for ground improvement generates significant excess pore water pressure and damages structure destruction, resulting in slight improvement of soil strength and appreciable settlement after grouting.
MENG Fanyan 1, 2, 3， TANG Yaofeng 1, 2, 3, ZHAO Rong 1, 2, 3, CHEN Tong 1, 2, 3, CHEN Renpeng 1, 2, 3
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Long-term settlement of tunnel caused by shield tunneling in peaty soil

Yantu gongcheng xuebao, 2017
In order to study the long-term settlement of tunnel caused by shield tunneling in peaty soil, the surrounding soil of tunnel is regarded as continuum, homogeneous and isotropic saturated viscoelastic medium.
WANG Zhi-liang , QU Jia-an , SHEN Lin-fang , XU Ze-min , DING Zu-de
doaj   +1 more source