Results 111 to 120 of about 185,019 (305)

Generation and Dissipation of Excess Pore Pressure During Pressuremeter Tests

Soils and Foundations, 1989
Laboratory tests were carried out to simulate pressuremeter testing so that the generation and dissipation of pore water pressure during pressuremeter tests could be studied. A modified triaxial cell was used to accomodate 150 mm hollow cylinder specimens prepared with known stress history.
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Stability Analysis of Coastal Sheet Pile Wall Considering Soil Weakening Induced by Earthquake Loading

Journal of Marine Science and Engineering
A sheet pile wall is a widely used retaining structure in coastal and riverbank areas. In liquefiable soils, seismic activity can generate excess pore pressure, which not only increases the load on the sheet pile wall but also reduces the soil strength ...
Shuai Ning, Qiang Ma, Yuan Cao
doaj   +1 more source

Predictions of changes in pore-water pressure around tunnels in clay [PDF]

Any underground construction causes changes to the stress state in the ground and this change generally causes the generation of excess pore-water pressures in saturated fine grained soils.
Divall, S., Goodey, R.J., Stallebrass, S. E., Taylor, R.N.   +3 more
core  

Transformation criteria rock strength in the presence of excess pore fluid pressure [PDF]

, 2018
Теоретичні дослідження геомеханічних процесів з використанням аналітичних математичних методів.
Солодянкин, А. В., Сторчак, Г. Г., Халимендик, А. В., Шаповал, В. Г., Шашенко, А. Н.   +4 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The effect of pore water pressure distribution induced by rainfall infiltration on the failure of unsaturated soil slopes [PDF]

E3S Web of Conferences
Numerical analysis was performed based on the Material Point Method (MPM) to analyze the failure mechanisms of unsaturated slopes due to rainfall infiltration. A coupled hydro-mechanical finite element model was applied to solve the rainfall infiltration
Lee Kwangwoo, Ferrari Alessio, Laloui Lyesse   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

In-situ tests on pore-water pressure response and consolidation mechanism of surface sediments in tidal flat of Yellow River Delta under tide and wave loading

Yantu gongcheng xuebao
In order to study the pore pressure response and consolidation mechanism of the surface sediments in the tidal flat of the Yellow River Delta under the action of wave and tide loading, the fluid sediments imitating the rapidly deposited seabed silty ...
ZHANG Jianmin 1, 2, SHAN Hongxian 3, WANG Zhenqiang 1, 2, WANG Zhicai 1, 2, WANG Jinjin 1, 2
doaj   +1 more source