Results 91 to 100 of about 44,035 (298)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Stresses and excess pore pressure induced in saturated poroelastic halfspace by moving line load [PDF]

open access: yes, 2004
This paper examines stresses and excess pore fluid pressure that are induced in a saturated poroelastic soil of halfspace extent by a concentrated line load.
B Jin   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Study of factors affecting shale gas adsorption by simplified local density-Peng–Robinson method

open access: yesEnergy Exploration & Exploitation, 2017
Shale gas has become an important source of natural gas, and a significant portion of gas in the reservoir exists in an adsorbed state. Thus, knowledge of gas adsorption behavior is important to estimate original gas in place and shale gas production. In
Wei Guo   +4 more
doaj   +1 more source

Long-term settlement of tunnel caused by shield tunneling in peaty soil

open access: yesYantu gongcheng xuebao, 2017
In order to study the long-term settlement of tunnel caused by shield tunneling in peaty soil, the surrounding soil of tunnel is regarded as continuum, homogeneous and isotropic saturated viscoelastic medium.
WANG Zhi-liang , QU Jia-an , SHEN Lin-fang , XU Ze-min , DING Zu-de
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Development of Dissipation Model of Excess Pore Pressure in Liquefied Sandy Ground [PDF]

open access: yes, 2009
Recently, several studies on the dissipation of excess pore pressure in liquefied sandy grounds have been reported on evaluation of postliquefaction behavior of structures.
Ko, Hon-Yim   +3 more
core   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Generalized shear strain-based model for development of excess pore water pressure in saturated sand under anisotropic consolidation

open access: yesYantu gongcheng xuebao
The development pattern of the excess pore water pressure in saturated sand under anisotropic consolidation conditions is crucial for understanding the liquefaction behavior of sand.
ZHAO Futang, WU Qixin, ZHENG Junjie, ZHENG Yewei
doaj   +1 more source

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