Results 71 to 80 of about 185,019 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Giant osmotic pressure in the forced wetting of hydrophobic nanopores [PDF]
, 2015 The forced intrusion of water in hydrophobic nanoporous pulverulent material is of interest for quick storage of energy. With nanometric pores the energy storage capacity is controlled by interfacial phenomena.
Charlaix, Elisabeth +3 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Multilayer approximation for a confined fluid in a slit pore [PDF]
, 2010 A simple Lennard-Jones fluid confined in a slit nanopore with hard walls is studied on the basis of a multilayer structured model. Each layer is homogeneous and parallel to the walls of the pore.
A. G. Meyra +5 more
core +4 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Open GeosciencesTo study the liquefaction problem of the dam foundation of an ultra-deep overburden in the strong earthquake area, a large-scale shaking table model test is carried out based on a 500 m rockfill dam project on an ultra-deep overburden.
Xing Yang +4 more
doaj +1 more source
Analysing consolidation data to optimise elastic visco-plastic model parameters for soft clay [PDF]
, 2015 University of Technology Sydney. Faculty of Engineering and Information Technology.Analysing the behaviour of soft soils under embankments is a significant challenging task for geotechnical engineers.
Le, TM
core
Dynamic Behavior of Bed Material around Bridge Pier under Abrupt Change of Water Pressure [PDF]
, 1999 Major failure of structures usually occurs during flood flows due to scourin, sinking and sliding. These types of failure are considered to be in close relation to the dynamic behavior of bed material around the structures.
Mia, Faruque, Nago, Hiroshi
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source