Results 71 to 80 of about 3,148,287 (203)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Excess pore pressure and slope failures resulting from gas-hydrates dissociation and dissolution

, 2007
Parameters affecting gas hydrate formation include temperature, pore pressure, gas chemistry, and pore-water salinity. Any change in the equilibrium of these parameters may result in dissociation (gas-hydrate turns into free gas/water mixture) and/or ...
Sultan, Nabil
core   +3 more sources

Excess pore water pressure generation in fine granular materials under cyclic loading -A laboratory study

, 2021
Excess pore water pressure can be generated in subgrades of both railway and pavement sub-structures under cyclic loading caused by heavy traffic. When saturated subgrades are subjected to cyclic loading, excess pore water pressures accumulate over time ...
Do, Tan Manh
core   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Determining the end of primary consolidation parameters based on settlement and excess pore water pressure [PDF]

Archives of Civil Engineering
The multiple-stage loading with reloading at EOP tests were carried out on two high-plasticity remoulded clays. One percentage of the initial value of an excess pore water pressure has been adopted as a reference for the end of the primary consolidation ...
Bartłomiej Szczepan Olek
doaj   +1 more source

Elasto-plasticity and pore-pressure coupled analysis on the pullout behaviors of a plate anchor

, 2015
A numerical method is proposed for the elasto-plasticity and pore-pressure coupled analysis on the pullout behaviors of a plate anchor. The bounding-surface plasticity (BSP) model combined with Biot's consolidation theory is employed to simulate the ...
Hu C(胡存), Gao FP(高福平)
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Study of factors affecting shale gas adsorption by simplified local density-Peng–Robinson method

Energy Exploration & Exploitation, 2017
Shale gas has become an important source of natural gas, and a significant portion of gas in the reservoir exists in an adsorbed state. Thus, knowledge of gas adsorption behavior is important to estimate original gas in place and shale gas production. In
Wei Guo, Luo Zuo, Rongze Yu, Xiaowei Zhang, Li Wang   +4 more
doaj   +1 more source