Results 61 to 70 of about 783,699 (277)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sex-specific and generational effects of alcohol and tobacco use on epigenetic age acceleration in the Michigan longitudinal study

Drug and Alcohol Dependence Reports, 2022
Background: Excessive alcohol and tobacco use are risk factors for poor health in both men and women, but use patterns and relationships with diseases and mortality differ between sexes.
Amir Carter, Cristina Bares, Lisha Lin, Beth Glover Reed, Marjorie Bowden, Robert A. Zucker, Wei Zhao, Jennifer A. Smith, Jill B. Becker   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sloshing in medium sized tanks under earthquake load

Građevinar, 2015
This paper presents results obtained by numerical study of sloshing effects in medium sized rectangular tanks subjected to a long-period seismic excitation.
Ersan Güray, Gökhan Yazıcı
doaj   +1 more source

Experimental Investigation of a Base Isolation System Incorporating MR Dampers with the High-Order Single Step Control Algorithm

Applied Sciences, 2017
The conventional isolation structure with rubber bearings exhibits large deformation characteristics when subjected to infrequent earthquakes, which may lead to failure of the isolation layer.
Weiqing Fu, Chunwei Zhang, Li Sun, Mohsen Askari, Bijan Samali, Kwok L. Chung, Pezhman Sharafi   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Numerical studies of photon acceleration in laser wakefields [PDF]

, 2004
This chapter looks at numerical studies of photon acceleration in laser ...
Mendonca, Jose Tito, Trines, Raoul M. G. M., Reitsma, Albert, Bingham, Robert, Norreys, P.A., Murphy, C.D.   +5 more
core   +4 more sources

CUDA-based parallel acceleration algorithm for wavelet denoising of airborne γ-ray spectrometry data

He jishu
BackgroundThe volume of aviation gamma spectrum data is immense. If only a central processing unit (CPU) is used for data post-processing, it would be constrained by computational efficiency.PurposeThis study aims to propose a CUDA-based graphics ...
XIONG Chao, WANG Xin, WANG Xinjie, WU Hexi   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

On research of the vehicle conversion effects on dynamic performance degradation [PDF]

Scientific Technical Review, 2016
Upon the vehicle conversion, the converter should ensure before putting the vehicle into service, that the modifications, carried out on the baseline vehicle, do not inhibit the ability of the converted vehicle to properly and surely perform its function.
Khettou Nabil, Trifković Dragan, Muždeka Slavko, Grkić Aleksandar, Perić Sreten   +4 more
doaj