Results 71 to 80 of about 1,215,052 (269)

Relationship between Lower Limb Kinematics and Upper Trunk Acceleration in Recreational Runners

open access: yesJournal of Healthcare Engineering, 2020
Upper trunk (UT) kinematics in runners and its relationship with lower limbs has been poorly investigated, although it is acknowledged that dynamic stability of the upper body is a primary objective of human locomotion.
L. Simoni   +4 more
semanticscholar   +1 more source

Rapid Variability in the SOL2011-08-04 Flare: Implications for Electron Acceleration

open access: yes, 2019
Particle acceleration in solar flares remains an outstanding problem in solar physics. It is currently unclear which of the acceleration mechanisms dominates and how exactly the excessive magnetic energy is transferred to nonthermal and other forms of ...
Fleishman, Gregory D.   +3 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

Interpretation of ultra-high energy multi-messenger data

open access: yesEPJ Web of Conferences, 2013
Charged ultra-high energy cosmic rays above ∼1017 eV are most likely accelerated in powerful astrophysical objects that have to meet a number of requirements to reach energies beyond the highest energies observed, a few 1020 eV, among them sufficient ...
Sigl Günter
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Does excess body weight accelerate immune aging?

open access: yesExperimental Gerontology
Overweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic inflammation and thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion in T lymphocytes. Therefore, the study was designed to explain whether excess body mass in older individuals affected the ...
Anna Tylutka   +3 more
openaire   +3 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Theoretical estimation of roll acceleration in beam seas using PDF line integral method

open access: yes, 2021
The prevention of excessive roll acceleration is one of the fundamental requirements of an oceangoing vessel at sea. In this paper, aiming at this requirement, we propose a new theoretical method for calculating roll angular acceleration, called “PDF ...
Fukumoto, Yusuke   +6 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Sloshing in medium sized tanks under earthquake load

open access: yesGrađevinar, 2015
This paper presents results obtained by numerical study of sloshing effects in medium sized rectangular tanks subjected to a long-period seismic excitation.
Ersan Güray, Gökhan Yazıcı
doaj   +1 more source

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