Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Effects of the Exchange Rate Policy of NBU for Socio-economic Development
The article discusses some aspects of the monetary policy and exchange rate regime, the Activities of the National Bank of Ukraine on ensuring the stability of hryvnia in the conditions of the floating exchange rate and inflation targeting.
Dmytro Dyakovskyy
doaj +1 more source
Cointegration and the stabilizing role of exchange rates [PDF]
We show that empirical results concerning the behavior of floating exchange rates differ between otherwise identical cointegrated and non-cointegrated VAR models. In particular, virtually all ten-year movements in nominal exchange rates are due to fundamental supply and demand shocks when long run equilibrium relationships between the levels of the ...
Alexius, Annika, Post, Erik
openaire +2 more sources
Price Stability and the Case for Flexible Exchange Rates [PDF]
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cuche-Curti, Nicolas A. +2 more
openaire +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Exchange Rate Regimes and Financial Sector Stability in Nigeria
Purpose: This paper examined the role of exchange rate regimes in the stability of the financial sector in Nigeria, on the context of a long standing exchange rate volatility and the frequency of the exposure of the banking sector in an oil-intensive ...
Kayode David Kolawole
doaj +1 more source
Exchange Rate Volatility and Trade Balance Dynamics in Nigeria: Evidence from a Nonlinear ARDL Approach [PDF]
This study examines the impact of exchange rate volatility on Nigeria’s trade balance using quarterly data from Q1 1990 to Q4 2025. The study employs Autoregressive Distributed Lag (ARDL) and Nonlinear ARDL (NARDL) models to capture both symmetric and ...
Tomilola Oloye, Tajudeen Egbetunde
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source

