Results 21 to 30 of about 251,277 (215)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The private ECU’s potential impact on global and European exchange rate stability

PSL Quarterly Review, 2013
This article examines the potential advantages and disadvantages of the creation of well-developed European Currency Unit (ECU) deposit and credit markets within the EEC. The major potential disadvantages are the higher speed of ECU creation and of intra-
H. JAGER, E . DE JONG
doaj   +1 more source

Trilemma Hypothesis: A Different Perspective on Turkey Economy

İstanbul İktisat Dergisi, 2020
The Trilemma Hypothesis continues to provide a macroeconomic framework with the trade-offs and challenges faced by policymakers, investors, and central banks. The Trilemma Hypothesis starting with Mundell-Fleming and developed by Frankel shows that in an
Havva Koç
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Impact of exchange rate dynamics on economic growth

Векторы благополучия: экономика и социум
This article explores the impact of exchange rate stability on economic growth in the context of increasing integration of national economies into global financial markets.
Nikita S. Malafeev, Tatiana G. Butorina, Maksim S. Svetlakov   +2 more
doaj   +1 more source

The contribution of the ECU to exchange-rate stability. A comment

PSL Quarterly Review, 2013
The article is a brief note criticising some essential elements of Jager and De Jong’s The private ECU’s potential impact on Global and European exchange-rate stability (1988).
M. SARCINELLI
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

L'impatto potenziale dell'ECU privato sulla stabilità di cambio globale ed europea. (The private ECU’s potential impact on global and European exchange rate stability)

Moneta e Credito, 2013
Questo articolo esamina i potenziali vantaggi e svantaggi della creazione di mercati ben sviluppati European Currency Unit (ECU) di deposito e di credito nell'ambito della CEE.
H. JAGER, E. DE JONG
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source