Results 61 to 70 of about 31,637 (190)

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

A method for large volume blood sampling and transfusion in rats

, 1986
A new protocol that makes it feasible to withdraw large volumes of whole blood from an individual rat within 1 h or less is described. This method involves the use of indwelling catheters for withdrawal of blood from the inferior vena cava with ...
W. B. Laughton, H. R. Berthoud, T. L. Powley   +2 more
core   +1 more source

Perioperative Management for Patients With Spinal Muscular Atrophy Undergoing Scoliosis Surgery: A Single‐Center Retrospective Study

Orthopaedic Surgery, EarlyView.
This largest Asian case series confirms that posterior spinal fusion for SMA scoliosis is safe and effective despite severe deformity and markedly impaired pulmonary function. Meticulous multidisciplinary care, including advanced airway planning, hemodynamic support, blood management, and proactive electrolyte correction, is critical to optimizing ...
Ai Hu, Xiuhua Zhang, Lulu Ma, Haisong Lu, Yulei Dong, Weiyun Chen, Yuguang Huang, Jianxiong Shen   +7 more
wiley   +1 more source

Manual RBC exchange transfusion in a patient of sickle-beta thalassemia syndrome presenting in crisis: a case report

, 2017
Sickle cell disease and beta thalassemia are caused by abnormal haemoglobin (Hb) derived from mutation of the HBB gene encoding beta-globin. Compound heterozygous status for both mutations results in HbS/beta thalassemia (Sickle- beta thalassemia).
Bibudhendu Pati, Girija Nandini Kanungo, Hemlata Das, Suman Sudha Routray   +3 more
core   +1 more source

Systemic barriers to donation for African, Caribbean and Black communities: A qualitative key informant study

Transfusion Medicine, EarlyView.
Abstract Background and Objective For many blood collection agencies (BCAs), meeting the transfusion needs of people living with sickle cell disease, a genetic condition that causes sickling of red blood cells, is a priority but also a challenge because of a lack of diversity in the donor base.
Jennie Haw, Joyeuse Senga, Dzifa Dordunoo, Biba Tinga   +3 more
wiley   +1 more source

Unraveling complexity: A case report on ABO hemolytic disease of the fetus newborn in a preterm neonate and delayed hemolytic transfusion reaction in the beta thalassemic mother due to alloanti kidd a antibody

Asian Journal of Transfusion Science
ABO hemolytic disease of the fetus and newborn (HDFN) generally occurs due to transplacental passage of maternal IgG ABO antibodies causing fetal and newborn red cell hemolysis.
V. K. Nayana, Satya Prakash, Somnath Mukherjee, Ansuman Sahu, K. Stephy Varghese, Debasish Mishra   +5 more
doaj   +1 more source

Intra‐apheresis CD34+ cell count: A dynamic approach to predicting peripheral blood stem cell collection yield

Transfusion, EarlyView.
Abstract Background Accurate prediction of peripheral blood stem cell (PBSC) yield is essential for optimizing hematopoietic stem cell collections. Traditional CD34+ prediction formulas often overlook the ongoing recruitment of CD34+ cells during the collection procedure.
Abdullah Alswied, Linda Song, Mame Thioye‐Sall, Leonard N. Chen, Kamille West‐Mitchell, Nan Zhang, Ping Jin, David Stroncek, Anh Dinh   +8 more
wiley   +1 more source

Hydroxyurea for Malignant Pertussis in Critically Ill Children

Critical Care Explorations
OBJECTIVES:. Malignant pertussis, the most severe manifestation of Bordetella pertussis infection, is characterized by multiple organ failure and a high mortality rate despite advanced intensive care measures.
Matthieu Blanc, MD, Clémence Marais, MD, MSc, Alexandre Debs, MD, Vladimir L. Cousin, MD, Pierre Tissières, MD, DSc, on behalf of the Paris Saclay Neonatal and Pediatric ICU Research Alliance (PANDORA) Study Group, Melissa Beggaz, MD, Matthieu Blanc, MD, Claire Boithias, MD, MSc, Charlotte Brognion, MD, Diane Carriere, MD, MSc, Ramy Charbel, MD, Caroline Claude, MD, MSc, Mafoudia Conde, MD, Vladimir L. Cousin, MD, Alexandre Debs, MD, Narjess Ghali, MD, Laure Jule, MD, Clémence Marais, MD, MSc, Jordi Miatello, MD, PhD, Luc Morin, MD, MSc, Francisco Oddone, MD, Arnaud Terzic, MD, Pierre Tissières, MD, DSc, Sarah Touati, MD, MSc.   +24 more
doaj   +1 more source

Safety and tolerability of amustaline/glutathione pathogen‐reduced red blood cells in neonatal rats

Transfusion, EarlyView.
Abstract Background Amustaline (S‐303)/glutathione (GSH) pathogen‐reduced red blood cells (PR‐RBCs) are in development for all adult and pediatric RBC transfusion indications, including neonates and infants. A neonatal rat model evaluated the safety and tolerability of PR‐RBCs during growth and maturation. Study Design and Methods Repeated transfusions
Anne North, Laurence Corash, Richard J. Benjamin, Nina Mufti   +3 more
wiley   +1 more source