Results 111 to 120 of about 2,256,376 (371)

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

Developing World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

Novel Peri-Operative Strategy for Sickle Cell Disease with Tetralogy of Fallot

Annals of Cardiac Anaesthesia
Peri-operative management of cyanotic congenital heart disease in a patient of sickle cell disease (SCD) can be challenging. We report a case of Tetralogy of Fallot and homozygous SCD with history of multiple blood transfusions and sickle cell crises who
Naveed Khan, Vaibhav Dhabe, Ameya Kaskar, Parthiban Kuppusamy, Supratim Sen, Gaurav Kumar   +5 more
doaj   +1 more source

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin

The FEBS Journal, EarlyView.
We characterize the PLTL lectin from Photorhabdus laumondii, which adopts a unique TNF‐like fold. Binding assays reveal a preference for branched histo‐blood group oligosaccharides. Protein crystallography uncovers a novel hexameric assembly and identifies key residues involved in carbohydrate recognition.
Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová   +7 more
wiley   +1 more source

Pilot study on the use of basophil activation tests and skin tests for the prevention of allergic transfusion reactions

Frontiers in Allergy
Background and objectivesManagement of severe allergic transfusion reactions (ATR) is challenging. In this study, we investigate the usefulness of skin tests and basophil activation tests (BAT) in chronically transfused patients for the prevention of ...
Philippe Akiki, Laurence Dedeken, Alina Ferster, Virginie Doyen, Gwendy Dupire, Carole Nagant, Julie Smet, Nathalie Ghorra, Isabelle Ruth, Maïlis Lauwers, Valery Daubie, Francis Corazza, Hanane El Kenz   +12 more
doaj   +1 more source

Blood transfusion practices in cardiac anaesthesia

Indian Journal of Anaesthesia, 2014
The primary reasons for blood transfusion in cardiac surgery are to correct anaemia and to improve tissue oxygen delivery. However, there is a considerable debate regarding the actual transfusion trigger at which the benefits of transfusion overweight ...
Hanumantha Rao Mangu, Aloka Samantaray, Muralidhar Anakapalli   +2 more
doaj   +1 more source

802 Causes and Contributing Factors Leading to Exchange Transfusion: 10 Year Experience at Adnan Menderes University Neonatal Intensive Care Unit [PDF]

, 2012
Münevver Türkmen, Defne Engür, Dilek Çolak, Seçil Oktay, Aydoğan Aydoğdu, Ayşe Tosun   +5 more
openalex   +1 more source

Five‐Year Experience of Haemophilia Centre Certification Performed by the German, Austrian and Swiss Society for Thrombosis and Haemostasis Research

Haemophilia, EarlyView.
ABSTRACT Introduction To enhance the treatment quality in haemophilia centres (HC), the German, Austrian and Swiss Society for Thrombosis and Haemostasis Research (GTH) started in 2017 the development of guidelines to define the structural and process quality of HC, essentially related to the EUHANET guidelines.
Hermann Eichler, Hagen Bönigk, Susan Halimeh, Christina Hart, Judith Hörner, Robert Klamroth, Ralf Knöfler, Christoph Königs, Thomas Lang, Florian Langer, Wolfgang Miesbach, Johannes Oldenburg, Ramona Oral, Martin Olivieri, Christian Pfrepper, Jan Pilch, Ute Scholz, Werner Streif, Manuela Albisetti   +18 more
wiley   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Effectiveness of Double-volume Exchange Transfusion in Neonates with Hyperbilirubinemia: A Single-center Experience

Global Journal of Transfusion Medicine
Background and Objectives: Double-volume exchange transfusion (DVET) is a life-saving procedure that replaces a neonate’s blood volume twice over with adult donor blood to treat neonatal hyperbilirubinemia and prevent kernicterus.
Kaushik Patra, Smita Mahapatra
doaj   +1 more source