Results 51 to 60 of about 149,013 (253)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The nature of acidity in selected acid soils
, 1977 Vita.Most of the soils in the eastern one-third of Texas are acid. To this date little work has been done to evaluate the acid status of these soils. The present effort was initiated to study total acidity and the contribution of the components to that ...
Carson, Charles Dee
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Soil Science Annual, 2017 The study has been undertaken in order to determine the influence of different substances (manure, clay, charcoal, zeolite and calcium oxide) on soil pH, hydrolytic acidity, total exchangeable bases, cation exchange capacity, the base saturation of soil ...
Kosiorek Milena, Wyszkowski Mirosław
doaj +1 more source
Agriculture & Food Security, 2021 Background Understanding the spatial variability of soil properties is useful to tailor site-specific agricultural inputs to enhance crop production on a sustainable basis.
Gedefa Sori +2 more
doaj +1 more source
Applied and Environmental Soil Science, 2023 Foumban, located in the Noun valley in western Cameroon, is a prime location for food production. However, this locality is experiencing a significant decline in productivity due to the acidity of its soil.
Vivien Piercy Lotse Tedontsah +7 more
doaj +1 more source
Simplifying Bayesian experimental design for multivariate partially exchangeable systems [PDF]
, 2000 We adopt a Bayes linear approach to tackle design problems with many variables cross-classified in many ways. We investigate designs where we wish to sample individuals belonging to different groups, exploiting the powerful properties of the adjustment ...
Shaw, Simon Charles, Shaw, S.C.
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source