mAbs, 2023 Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood ...
Chunting Zhang +11 more
doaj +1 more source
Nanoparticles in the treatment of chronic lung diseases [PDF]
, 2019 Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G +9 more
core +2 more sources
Microbiology Spectrum, 2021 Dimethyl sulfoxide (DMSO) and polyethylene glycols (PEGs) are frequently used as potent excipients in pharmaceutical formulations. However, these agents also have an interesting antimicrobial and anti-inflammatory profile that could interfere with the ...
Vijay K. Singh +2 more
doaj +1 more source
European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children. [PDF]
, 2017 © American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate ...
C Tuleu +28 more
core +4 more sources
Evaluation of Celecoxib-Lactose Incompatibility Reactions at Solid State using Physicochemical Methods [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2021 Background & Aims: Drug excipient incompatibility evaluation is an important part of pre-formulation studies. Drug-excipient interaction may affect drug stability, bioavailability, therapeutic effects, efficacy, and safety.
Ali Fattahzadeh +3 more
doaj
Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation [PDF]
, 2014 Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still
Larramendy, Marcelo Luis +3 more
core +2 more sources
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]
, 2014 The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi +8 more
core +1 more source
Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association
Antibodies, 2022 Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products ...
Lok Hin Lui +3 more
doaj +1 more source
A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]
, 2017 BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent +5 more
core +1 more source
Advanced Materials, EarlyView.A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee +8 more
wiley +1 more source