Results 51 to 60 of about 48,655 (322)

Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration

Pharmaceuticals, 2023
Mycobacterium tuberculosis (M.tb) has infected one-quarter of the world’s population and led to the deaths of 1.6 million individuals in 2021 according to estimates from the World Health Organization.
Sara E. Maloney, Ian E. Stewart, Brendan K. Podell, Hadley E. Gary, Jeffrey B. Mecham, Bryan J. Berube, Susan L. Baldwin, Rhea N. Coler, Anthony J. Hickey   +8 more
doaj   +1 more source

Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles [PDF]

, 2012
The utility of controlled release medication formulations lies in their ability to keep drugs at steady levels in the blood plasma of recipients and within the termini of the maximum and minimum effective therapeutic levels.
Mucalo, Michael R., Rathbone, Michael J.
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons

Frontiers in Pharmacology, 2018
Purpose: Drug coated balloons (DCB) are continually improving due to advances in coating techniques and more effective excipients. Paclitaxel, the current drug choice of DCB, is a microtubule-stabilizing chemotherapeutic agent that inhibits smooth muscle
Emily Turner, Megan Erwin, Marzieh Atigh, Uwe Christians, Justin M. Saul, Saami K. Yazdani   +5 more
doaj   +1 more source

Impact of Excipients on Stability of Polymer Microparticles for Autoimmune Therapy

Frontiers in Bioengineering and Biotechnology, 2021
Therapies for autoimmune diseases such as multiple sclerosis and diabetes are not curative and cause significant challenges for patients. These include frequent, continued treatments required throughout the lifetime of the patient, as well as increased ...
Emily A. Gosselin, Maeesha Noshin, Sheneil K. Black, Christopher M. Jewell, Christopher M. Jewell, Christopher M. Jewell, Christopher M. Jewell, Christopher M. Jewell   +7 more
doaj   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation

Pharmaceuticals
Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities.
Jiayi Huang, Shiqi Hong, Lucas Yuan Hao Goh, Hailong Zhang, Tao Peng, Keat Theng Chow, Rajeev Gokhale, Vinod Tuliani   +7 more
doaj   +1 more source

New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain

Frontiers in Endocrinology, 2022
Reducing injection-site pain (ISP) in patients with chronic conditions such as growth hormone deficiency is a valuable strategy to improve patient compliance and therapeutic efficiency.
Bita Taghizadeh, Mahmoud Reza Jaafari, Mahmoud Reza Jaafari, Nosratollah Zarghami, Nosratollah Zarghami   +4 more
doaj   +1 more source

Research and Review of Polymethyl-Methacrylate Copolymers in the Development of Enhanced Pharmaceutical Delivery Systems [PDF]

, 2020
The following thesis shall primarily explore the current research regarding the implementation of modifiable microscopic and nanoscopic polymer particles as novel pharmaceutical delivery systems. Polymethacrylate-based copolymers, such as EudragitTM, are
Dyess, Jake
core   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source