Results 71 to 80 of about 48,655 (322)

A New Perspective of Multiple Roller Compaction of Microcrystalline Cellulose for Overcoming Re-Compression Drawbacks in Tableting Processing

Applied Sciences, 2020
In this paper, new scientific insights in relation to the re-compaction of microcrystalline cellulose (MCC; Avicel®® PH-101) under specific compaction conditions are reported. MCC was subjected to multiple compaction cycles (1st, 2nd, and 3rd) under high
Deeb Abu Fara, Iyad Rashid, Linda Al-Hmoud, Babur Z. Chowdhry, Adnan A. Badwan   +4 more
doaj   +1 more source

Development of a Potent Stabilizer for Long-Term Storage of Foot-and-Mouth Disease Vaccine Antigens

Vaccines, 2021
A local virus isolate, O/SKR/JC/2014 (O JC), has been considered as a candidate vaccine strain in the development of a domestic foot-and-mouth disease (FMD) vaccine in Korea.
Ah-Young Kim, Hyejin Kim, Sun Young Park, Sang Hyun Park, Jae-Seok Kim, Jung-Won Park, Jong-Hyeon Park, Young-Joon Ko   +7 more
doaj   +1 more source

Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride [PDF]

, 2006
A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized. The in vitro dissolution profiles of sustained-release matrix tablets of racemic PPL were determined and compared with the United States Pharmacopeia
Bataille, Bernard, Castellanos Gil, Eddy, Heinämäki, Jyrki, Iraizoz Colarte, Antonio, Pedraz, José Luis, Rodriguez, Fernand   +5 more
core   +2 more sources

Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]

, 2020
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham, Chen, Xing, Nikolakakis, Ioannis, Partheniadis, Ioannis   +3 more
core   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model

Pharmaceutics, 2020
This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets.
Atsushi Kosugi, Kok Hoong Leong, Eri Urata, Yoshihiro Hayashi, Shungo Kumada, Kotaro Okada, Yoshinori Onuki   +6 more
doaj   +1 more source

Citric Acid: A Multifunctional Pharmaceutical Excipient

Pharmaceutics, 2022
Citric acid, a tricarboxylic acid, has found wide application in the chemical and pharmaceutical industry due to its biocompatibility, versatility, and green, environmentally friendly chemistry.
Maria Lambros, Thac (Henry) Tran, Qinqin Fei, Mike Nicolaou   +3 more
doaj   +1 more source

Processing-Induced Disorder in Pharmaceutical Materials [PDF]

, 2016
This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally.
Al-Obaidi, Alkhatib, Alonzo, Bahl, Balani, Breitenbach, Brough, Brown, Cal, Cerea, Chakraborty, Chattoraj, Chieng, Clark, Cordeiro, Cui, De Beer, Descamps, DiNunzio, Dinunzio, El-Badry, Elamin, Felton, Feng, Forster, Gazzaniga, Graeser, Guns, Gupta, He, Hu, Hu, Janssens, Kang, Karmwar, Ke, Keen, Khan, Kim, Koivisto, Lai, Laitinen, Laitinen, Lang, Lauer, Luisi, Luo, Löbmann, Löbmann, Nagy, Ng, Norrman, Otte, Otte, Passerini, Patterson, Porter, Qi, Qi, Qi, Qi, Repka, Riippi, Saerens, Sammoura, Santivarangkna, Sauer, Sauer, Sill, Sollohub, Tang, Trasi, Trasi, Van den Brande, Van Eerdenbrugh, Van Eerdenbrughand, Van Melkebeke, Vehring, Weatherley, Weuts, Willart, Willart, Willart, Williams, Windbergs, Windbergs, Wojnarowska, Yang, Zamani, Zema   +89 more
core   +1 more source

Work‐Related Asthma From Exposure to Cardboard and Paper Products

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background We assess the contribution of cardboard dust exposure to the development of work‐related asthma (WRA). Prior studies on paper‐dust‐related breathing problems have focused on exposures in the paper milling and pulp industries. There have been no reports of asthma linked to workplace exposure to cardboard dust.
Mason E. Glanville, Mary Jo Reilly, Kenneth D. Rosenman   +2 more
wiley   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, EarlyView.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source