Results 131 to 140 of about 45,262,696 (341)
Journal of Cancer Research and TherapeuticsIN such an act as the flexion-reflex, one group of muscles (flexors) contracts, and the antagonistic group (extensors) relaxes-if they have previously been in a state of tonic contraction.
semanticscholar +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Power main circuit design of the flexible excitation systems for large hydropower units
Zhejiang dianliIn response to the system voltage stability and damping issues caused by insufficient dynamic reactive power support capability of renewable energy units， this paper proposes a novel power main circuit topology for flexible excitation systems suitable ...
YAN Wenci +6 more
doaj +1 more source
Linear Active Disturbance Rejection Control for Flexible Excitation System of Pumped Storage Units
The role of pumped storage in global energy structure transformation is becoming increasingly prominent. This article introduces a flexible excitation system based on fully controlled device converters into pumped storage units (PSUs). It can address the
Xinyu Cheng +6 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
STATISTICAL LINEARIZATION METHOD OF DUFFING OSCILLATOR UNDER GAUSSIAN WHITE NOISE EXCITATION [PDF]
In this paper is presented a statistical linearization method of Duffing oscillator under Gaussian white noise excitation. Duffing oscillator’s dispersion response to various nonlinearities and spectral intensities is obtained by the statistical ...
Ovidiu Solomon
core
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source