Results 111 to 120 of about 2,374,265 (295)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Psicología y discapacidad: un encuentro desde el paradigma social

open access: yesRevista Costarricense de Psicología, 2014
El tema de la discapacidad ha sido abordado desde diversos paradigmas o modelos que han dictado el modo de brindar atención a personas con esta condición.
Lucrecia Alfaro-Rojas
doaj  

Las rentas mínimas de inserción autonómicas: simulación de sus efectos sobre la pobreza [PDF]

open access: yes, 2013
Las rentas mínimas de inserción constituyen el último eslabón del sistema de protección contra la pobreza y la exclusión social en España. En este trabajo analizamos sus características y simulamos la normativa de cada una de las Comunidades Autónomas ...
Fuenmayor Fernández, Amadeo   +1 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Adolescentes, exclusión y vulnerabilidades [PDF]

open access: yes, 2012
publishedVersio
Carreteiro, Teresa Cristina
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Porvenir y política de los obstáculos de aprendizaje [PDF]

open access: yes, 2012
Los obstáculos de aprendizaje para un cierto grupo de estudiantes se pueden establecer de maneras explícitas como, por ejemplo, la sujeción a una política absurda.
Skovsmose, Ole
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Alumnas en el internado de los hospitales de París (1871-1910). Procesos de exclusión e inclusión [PDF]

open access: yes, 2016
En este trabajo se abordan los mecanismos de exclusión explícitos e implícitos que limitaron el acceso de las mujeres al internado de los hospitales de París en las últimas décadas del siglo XIX, a través del examen de la documentación generada en el ...
Ruiz Somavilla, María José
core   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Home - About - Disclaimer - Privacy