Results 171 to 180 of about 2,053,307 (308)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

La Escuela Rural de Utawilaya y los adventistas en el Altiplano Puneño 1898 – 1920: Precursora de la educación rural indígena peruana y Latinoamericana

open access: yesRevista Historia de la Educación Latinoamericana, 2017
La investigación sobre el desarrollo de la “Escuela Rural de Utawilaya y los Adventistas en el Altiplano puneño 1898 – 1920”, ubicada en la provincia de Puno del sur peruano, presenta como actor relevante al educador Manuel Zúñiga Camacho, fundador de ...
David Ruelas Vargas
doaj  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Role of medico-administrative database in the selection of the target population in colorectal cancer screening program. [PDF]

open access: yesTherap Adv Gastroenterol
Koïvogui A   +6 more
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Protective Factors Against Social Exclusion in Adolescents: Physical Condition and Physical Activity. [PDF]

open access: yesChildren (Basel)
Rodríguez-Negro J   +4 more
europepmc   +1 more source

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