Results 141 to 150 of about 565,650 (262)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Vivienda y exclusión social

, 2004
El Comité Español para el Bienestar Social (CEBS) va celebrar un Foro para la Integración Laboral de Personas en Riesgo de Exclusión dins del qual es va incloure un Seminari específic sobre Exclusió Social. Tant el projecte global com l'esmentat Seminari
Trilla, Carme
core  

Candidate transdiagnostic processes linking potentially traumatic experiences to psychopathology, mental well-being and resilience in emerging adults. [PDF]

BMC Psychiatry
Cohrdes C, Birgel V, Entringer S, Rapp M, Tschorn M, Hölling H.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Estudio y diagnóstico de las situaciones de exclusión residencial en zonas rurales del municipio de Cartagena [PDF]

© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.Las sucesivas crisis (financiera, sanitaria, energética) han aumentado los riesgos sociales de muchas personas, de ...
García Luque, Olga, Carbonell Aguirre, Inés, Manzanera-Román, Salvador, Solórzano Pérez, Gustavo, García Egea, Agustín, Hernández Pedreño, Manuel   +5 more
core  

Friendship fosters well-being, exclusion may hurt girls' mathematics: a two-wave cross-lagged panel model of peer relations, affect, and achievement. [PDF]

Eur J Psychol Educ
Lintner T.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Investigating the interplay between social exclusion and meaning in life: the catalytic influence of psychological flexibility and basic psychological needs. [PDF]

BMC Psychol
Li Q, Zhang Z, Ge M, Wang Y, Wang X.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Social exclusion and mobile phone dependence in college students: a moderated mediation model of self-control and social self-efficacy. [PDF]

Front Psychol
Lv L, Huang J, Cao Y.
europepmc   +1 more source